SynthesisNutrients2023
The Effects of Flavonoids on Skeletal Muscle Mass, Muscle Function, and Physical Performance in Individuals with Sarcopenia: A Systematic Review of Randomized Controlled Trials.
Synthesis in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Effect of Polyphenol-Rich Diet Combined with Leucine, Vitamin D3, and Magnesium Supplementation on Self-Reported Mobility and Health Perception in Adults at Risk of Sarcopenia: A 3-Months Quasi-Experimental Study.Life (Basel, Switzerland) · 2026Article
- Bioactive Components ofAntioxidants (Basel, Switzerland) · 2026Review
- Association between low-carbohydrate diet and low-fat diet scores and sarcopenia as determined by dual-energy X-ray absorptiometry: a cross-sectional study.Nutrition journal · 2025Article
- Application of Exercise/Training Models to Evaluate Food Functionality with Special Focus on Preventing Inflammation and Oxidative Stress and Enhancing Exercise Performance.Foods (Basel, Switzerland) · 2025Review
- Molecular Mechanisms, Physiological Effects, Gut Microbiota Interplay and Nutritional Strategies of Anthocyanins as Modulators of Muscle Protein Synthesis: A Narrative Review.Current nutrition reports · 2025Review
- Nutraceutical Interception of Cachexia: Grape-Derived Compounds as Pathophysiological Network Modulators.Biology · 2025Review
- Advances in the Regulation by Immune Cells of Skeletal Myositis Outcomes.Aging and disease · 2025Review
- Article
- Nutritional Approach to Diabetic Sarcopenia: A Comprehensive Review.Current nutrition reports · 2025Review
- Article
- Bioavailability of Tea Polyphenols: A Key Factor in Understanding Their Mechanisms of Action In Vivo and Health Effects.Journal of agricultural and food chemistry · 2025Review
- Anti-Aging Effects of Flavonoids from Plant Extracts.Foods (Basel, Switzerland) · 2024Review
- Therapeutic Potential of Quercetin as an Antioxidant for Bone-Muscle-Tendon Regeneration and Aging.Aging and disease · 2024Review
- The Different Phytochemical Profiles ofMolecules (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcopenia has become a significant obstacle to healthy aging in older adults. Flavonoids may contribute to treating sarcopenia, and attenuate the age-related loss of skeletal muscle mass, muscle strength, and physical function, however, their benefits in sarcopenic individuals remain unclear. This systematic review aimed to evaluate the effect of flavonoids on muscle mass, muscle strength, and physical performance in adults with sarcopenia based on randomized controlled trials (RCTs). This review was conducted in conformity with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the risk of bias was assessed using the Cochrane risk of bias tool. The article search was conducted using PubMed, Scopus, Embase, Cochrane, Web of Science databases, and Google Scholar for the period until June 2023. RCTs that assessed the effects of flavonoids/flavonoids combined with other supplementation/flavonoid-rich supplementations on skeletal muscle mass, muscle strength, and physical performance in adults diagnosed with sarcopenia before intervention were included. From the 309 articles found, a total of 6 RCTs met the inclusion criteria. RCTs evaluated the main outcomes of tea catechins, epicatechin, and isoflavones intervention. Skeletal muscle mass significantly increased in three studies, muscle strength significantly elevated in two studies, and physical performance significantly improved in two studies. The majority of studies (five in six) found at least one of the main outcomes is elevated by flavonoids intervention. Flavonoids may have a great potential to treat sarcopenia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.