Evidence map›Paper›PMID 37764666›Full record

ArticleNutrients2023

ALDH1A Inhibition Suppresses Colitis and Alters α4β7 Integrin Expression on Activated T Cells in

Audrey Seamons, Olesya Staucean, Jessica M Snyder, Thea Brabb, Charlie C Hsu, Jisun Paik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Audrey SeamonsDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-2609-1230
Olesya StauceanDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
Jessica M SnyderDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
Thea BrabbDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
Charlie C HsuDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
Jisun PaikDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
University of Washington · US

Funding

Validation of ALDH1A1 as a target for the treatment of obesity: effects of ALDH1A1 inhibition on energy metabolismR01DK124197 · NIDDK · UNIVERSITY OF WASHINGTON · PI PAIK, JISUN · 2022 to 2024
$1.2M
NIDDK NIH HHS R01 DK124197
6 · The paper itself

Abstract

There are limited pharmacological treatment options for inflammatory bowel disease (IBD), and some of these options are expensive and administered by injection or infusion. Thus, new cheaper and easier (oral) treatment options are needed. ALDH1A enzymes produce retinoic acid that can affect intestinal diseases such as IBD by regulating immune cells in the gut. We previously demonstrated that an orally deliverable ALDH1A inhibitor, WIN 18,466, can suppress colitis in an acute mouse model of IBD. Here, we tested the efficacy of ALDH1A inhibition in a chronic mouse model of IBD.

Indexed as

ColitisInflammatory Bowel DiseasesAnimalsB-LymphocytesDisease Models, AnimalIntegrinsMiceIntegrinsALDH1A enzymesimmunityinflammatory bowel diseasemouse modelretinoic acid

Identifiers

PMID37764666
PMCPMC10536456
OpenAlexW4386484531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.