PEGA-BA@Ce6@PFCE Micelles as Oxygen Nanoshuttles for Tumor Hypoxia Relief and Enhanced Photodynamic Therapy.

Junan Zhang, Xiaoyun Jiang, Wenyue Luo, Yongjie Mo, Chunyan Dai, Linhua Zhu

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Chlorin Activity Enhancers for Photodynamic Therapy.Molecules (Basel, Switzerland) · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junan ZhangCollege of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.ORCID 0000-0002-9851-0898

Xiaoyun JiangCollege of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.

Wenyue LuoCollege of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.

Yongjie MoCollege of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.ORCID 0000-0002-1784-7801

Chunyan DaiCollege of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.ORCID 0009-0006-6401-9060

Linhua ZhuCollege of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.

Funding

Linhua Zhu 220CXTD436Linhua Zhu ZDYF2022SHFZ285

6 · The paper itself

Abstract

Tumor hypoxia, which is mainly caused by the inefficient microvascular systems induced by rapid tumor growth, is a common characteristic of most solid tumors and has been found to hinder treatment outcomes for many types of cancer therapeutics. In this study, an amphiphilic block copolymer, poly (ethylene glycol) methyl ether acrylate-block-n-butyl acrylate (PEGA-BA), was prepared via the ATRP method and self-assembled into core-shell micelles as nano radiosensitizers. These micelles encapsulated a photosensitizer, Chlorin e6 (Ce6), and demonstrated well-defined morphology, a uniform size distribution, and high oxygen loading capacity. Cell experiments showed that PEGA-BA@Ce6@PFCE micelles could effectively enter cells. Further in vitro anticancer studies demonstrated that the PEGA-BA@Ce6@PFCE micelles significantly suppressed the tumor cell survival rate when exposed to a laser.

Indexed as

MicellesNanoparticlesOxygenPhotochemotherapyPhotosensitizing AgentsPolyethylene GlycolsPorphyrinsTumor HypoxiaCell Line, TumorCell SurvivalChlorophyllidesHumansChlorophyllidesMicellesOxygenPhotosensitizing AgentsphytochlorinPolyethylene GlycolsPorphyrinsblock copolymerhypoxiaoxygen deliveryphotodynamic therapy

Identifiers

PMID37764473

DOI10.3390/molecules28186697

PMCPMC10535279

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.