ReviewMolecules (Basel, Switzerland)2023
The Methylcitrate Cycle and Its Crosstalk with the Glyoxylate Cycle and Tricarboxylic Acid Cycle in Pathogenic Fungi.
Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Functional Profiles of Fish Gut Microbiota Associated With Feeding Habits in the Midstream of the Jialing River Under Cascade Channelization.Ecology and evolution · 2026Article
- Mycobacterium tuberculosis VadK is required for the regulation of the methylcitrate cycle and virulence.EMBO reports · 2026Article
- Unveiling Metabolic Capability and Growth Adaptation ofInternational journal of molecular sciences · 2026Article
- Insights into the Adaptation ofJournal of fungi (Basel, Switzerland) · 2026Article
- Free ammonia stress rewires microbial signaling networks and constrains metabolic cooperation in oxygenic photogranules.The ISME journal · 2026Article
- Huangqin decoction disrupts energy metabolism of Trichophyton rubrum, with isocitrate lyase as a potential target.Scientific reports · 2026Article
- DVL, a Lectin fromAntibiotics (Basel, Switzerland) · 2025Article
- Decarboxylase mediated oxalic acid metabolism is important to antioxidation and detoxification rather than pathogenicity inVirulence · 2025Article
- Proteomic characterization ofVirulence · 2025Article
- Transcriptomics-based analysis of acetate and propionate transport and metabolism in Yarrowia lipolytica.Biotechnology for biofuels and bioproducts · 2025Article
- VadK, a Non-Canonical Kinase that Regulates the Methylcitrate Cycle and is Essential forbioRxiv : the preprint server for biology · 2025Article
- Mapping carbon utilization pathways inmSystems · 2025Article
- UV-Induced Mutants ofJournal of fungi (Basel, Switzerland) · 2025Article
- Cultivation methods and biology of Lentinula edodes.Applied microbiology and biotechnology · 2025Review
- Genetic and Physiological Characterization of the Pentose Phosphate Pathway in the YeastInternational journal of molecular sciences · 2025Article
- Metabolic pathway analysis of the methylcitrate cycle in bacteria and fungi identifies methylcitrate synthase as an antiinfective drug target.microLife · 2025Article
- A Meta-Analysis of the Human Gut Mycobiome Using Internal Transcribed Spacer Data.Microorganisms · 2024Article
- ChIP-Seq Analysis of AtfA Interactions inInternational journal of molecular sciences · 2024Article
- Corn straw-saccharification fiber improved the reproductive performance of sows in the late gestation and lactation via lipid metabolism.Frontiers in nutrition · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
In fungi, the methylcitrate cycle converts cytotoxic propionyl-coenzyme A (CoA) to pyruvate, which enters gluconeogenesis. The glyoxylate cycle converts acetyl-CoA to succinate, which enters gluconeogenesis. The tricarboxylic acid cycle is a central carbon metabolic pathway that connects the methylcitrate cycle, the glyoxylate cycle, and other metabolisms for lipids, carbohydrates, and amino acids. Fungal citrate synthase and 2-methylcitrate synthase as well as isocitrate lyase and 2-methylisocitrate lyase, each evolved from a common ancestral protein. Impairment of the methylcitrate cycle leads to the accumulation of toxic intermediates such as propionyl-CoA, 2-methylcitrate, and 2-methylisocitrate in fungal cells, which in turn inhibits the activity of many enzymes such as dehydrogenases and remodels cellular carbon metabolic processes. The methylcitrate cycle and the glyoxylate cycle synergistically regulate carbon source utilization as well as fungal growth, development, and pathogenic process in pathogenic fungi.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.