Evidence map›Paper›PMID 37764363›Full record

ArticleMolecules (Basel, Switzerland)2023

Using the Correlation Intensity Index to Build a Model of Cardiotoxicity of Piperidine Derivatives.

Alla P Toropova, Andrey A Toropov, Alessandra Roncaglioni, Emilio Benfenati

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alla P ToropovaIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Department of Environmental, Health Science, Via Mario Negri 2, 20156 Milano, Italy.ORCID 0000-0002-4194-9963
Andrey A ToropovIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Department of Environmental, Health Science, Via Mario Negri 2, 20156 Milano, Italy.ORCID 0000-0001-6864-6340
Alessandra RoncaglioniIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Department of Environmental, Health Science, Via Mario Negri 2, 20156 Milano, Italy.
Emilio BenfenatiIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Department of Environmental, Health Science, Via Mario Negri 2, 20156 Milano, Italy.

Funding

the European Union's Horizon 2020 research and innovation program 101037090
6 · The paper itself

Abstract

The assessment of cardiotoxicity is a persistent problem in medicinal chemistry. Quantitative structure-activity relationships (QSAR) are one possible way to build up models for cardiotoxicity. Here, we describe the results obtained with the Monte Carlo technique to develop hybrid optimal descriptors correlated with cardiotoxicity. The predictive potential of the cardiotoxicity models (

Indexed as

CardiotoxicityChemistry, PharmaceuticalHumansMonte Carlo MethodPiperidinesQuantitative Structure-Activity RelationshipPiperidinescardiotoxicitycomputational chemistryCORAL softwarecorrelation intensity indexMonte Carlo method

Identifiers

PMID37764363
PMCPMC10535953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.