Evidence map›Paper›PMID 37764336›Full record

ArticleMolecules (Basel, Switzerland)2023

A Standardized Botanical Composition Mitigated Acute Inflammatory Lung Injury and Reduced Mortality through Extracellular HMGB1 Reduction.

Mesfin Yimam, Teresa Horm, Alexandria O'Neal, Ping Jiao, Mei Hong, Lidia Brownell, Qi Jia, Mosi Lin, Alex Gauthier, Jiaqi Wu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Mesfin YimamUnigen Inc., 2121 South State Street, Suite #400, Tacoma, WA 98405, USA.
Teresa HormUnigen Inc., 2121 South State Street, Suite #400, Tacoma, WA 98405, USA.
Alexandria O'NealUnigen Inc., 2121 South State Street, Suite #400, Tacoma, WA 98405, USA.
Ping JiaoUnigen Inc., 2121 South State Street, Suite #400, Tacoma, WA 98405, USA.
Mei HongUnigen Inc., 2121 South State Street, Suite #400, Tacoma, WA 98405, USA.
Lidia BrownellUnigen Inc., 2121 South State Street, Suite #400, Tacoma, WA 98405, USA.ORCID 0000-0002-5328-0152
Qi JiaUnigen Inc., 2121 South State Street, Suite #400, Tacoma, WA 98405, USA.
Mosi LinCollege of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
Alex GauthierCollege of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
Jiaqi WuCollege of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
Kranti Venkat MatetiCollege of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
Xiaojian YangCollege of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
Katelyn DialCollege of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
Sidorela ZefiCollege of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
Lin L MantellCollege of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
St. John's University · USState Street (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HMGB1 is a key late inflammatory mediator upregulated during air-pollution-induced oxidative stress. Extracellular HMGB1 accumulation in the airways and lungs plays a significant role in the pathogenesis of inflammatory lung injury. Decreasing extracellular HMBG1 levels may restore innate immune cell functions to protect the lungs from harmful injuries. Current therapies for air-pollution-induced respiratory problems are inadequate. Dietary antioxidants from natural sources could serve as a frontline defense against air-pollution-induced oxidative stress and lung damage. Here, a standardized botanical antioxidant composition from

Indexed as

Acute Lung InjuryHMGB1 ProteinHyperoxiaAnimalsAntioxidantsCytokinesLipopolysaccharidesMiceAntioxidantsCytokinesHMGB1 ProteinLipopolysaccharidesHMGB1inflammatory lung injuryoxidative stresssepsis

Identifiers

PMID37764336
PMCPMC10538186
OpenAlexW4386602025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.