Evidence map›Paper›PMID 37764307›Full record

ArticleMolecules (Basel, Switzerland)2023

Screening of Anti-Inflammatory Activity and Metabolomics Analysis of Endophytic Fungal Extracts; Identification and Characterization of Perylenequinones and Terpenoids from the Interesting Active Alternaria Endophyte.

Rosella Spina, Armelle Ropars, Sihem Bouazzi, Safa Dadi, Pascal Lemiere, François Dupire, Afra Khiralla, Sakina Yagi, Jean-Pol Frippiat, Dominique Laurain-Mattar

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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  7. Induced effect of NaWorld journal of microbiology & biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Rosella SpinaUniversité de Lorraine, INRAE, LAE, F-54000 Nancy, France.ORCID 0000-0003-0969-2587
Armelle RoparsUniversité de Lorraine, SIMPA, F-54000 Nancy, France.ORCID 0000-0001-7340-7934
Sihem BouazziUniversité de Lorraine, CNRS, L2CM, F-54000 Nancy, France.
Safa DadiUniversité de Lorraine, CNRS, L2CM, F-54000 Nancy, France.
Pascal LemiereUniversité de Lorraine, CNRS, L2CM, F-54000 Nancy, France.
François DupireUniversité de Lorraine, CNRS, L2CM, F-54000 Nancy, France.ORCID 0000-0001-5038-723X
Afra KhirallaBotany Department, Faculty of Sciences and Technologies, Shendi University, Shendi 11111, Sudan.ORCID 0000-0001-7670-0378
Sakina YagiDepartment of Botany, Faculty of Science, University of Khartoum, Khartoum 11115, Sudan.
Jean-Pol FrippiatUniversité de Lorraine, SIMPA, F-54000 Nancy, France.ORCID 0000-0002-4027-6269
Dominique Laurain-MattarUniversité de Lorraine, INRAE, LAE, F-54000 Nancy, France.ORCID 0000-0001-7013-8505
Centre National de la Recherche Scientifique · FRInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · FRStress, immunité, pathogènesShendi University · SDUniversity of Khartoum · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients suffering from inflammatory chronic diseases are classically treated with anti-inflammatory drugs but unfortunately are highly susceptible to becoming resistant to their treatment. Finding new drugs is therefore crucial and urgent and research on endophytic fungi is a promising way forward. Endophytic fungi are microorganisms that colonize healthy plants and live within their intercellular tissues. They are able to produce a large variety of secondary metabolites while allowing their host to stay healthy. A number of these molecules are endowed with antioxidant or antimicrobial as well as cytotoxic properties, making them very interesting/promising in the field of human therapy. The aim of our study was to investigate whether extracts from five endophytic fungi isolated from plants are endowed with anti-inflammatory activity. Extracts of the endophytic fungi

Indexed as

AlternariaAnti-Inflammatory AgentsEndophytesMetabolomicsPeryleneTerpenesAspergillusHumansLipopolysaccharidesMacrophagesTHP-1 CellsAnti-Inflammatory AgentsLipopolysaccharidesPeryleneTerpenesAlternaria alternataanti-inflammatory activityendophytic fungiGNPSmolecular networkperylenequinones

Identifiers

PMID37764307
PMCPMC10534442
OpenAlexW4386602240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.