Evidence map›Paper›PMID 37764297›Full record

ArticleMolecules (Basel, Switzerland)2023

Development and Assessment of 1,5-Diarylpyrazole/Oxime Hybrids Targeting EGFR and JNK-2 as Antiproliferative Agents: A Comprehensive Study through Synthesis, Molecular Docking, and Evaluation.

Kamal S Abdelrahman, Heba A Hassan, Salah A Abdel-Aziz, Adel A Marzouk, Raef Shams, Keima Osawa, Mohamed Abdel-Aziz, Hiroyuki Konno

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Kamal S AbdelrahmanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.ORCID 0000-0002-2661-6159
Heba A HassanDepartment of Medicinal Chemistry Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Salah A Abdel-AzizDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Adel A MarzoukDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Raef ShamsEmergent Bioengineering Materials Research Team, RIKEN Centre for Emergent Matter Science, RIKEN, Wako 351-0198, Saitama, Japan.ORCID 0000-0003-4359-7030
Keima OsawaGraduate School of Science and Engineering, Yamagata University, Yonezawa 992-8510, Yamagata, Japan.
Mohamed Abdel-AzizDepartment of Medicinal Chemistry Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Hiroyuki KonnoGraduate School of Science and Engineering, Yamagata University, Yonezawa 992-8510, Yamagata, Japan.ORCID 0000-0002-6629-6102
Al-Azhar University · EGMinia University · EGYamagata University · JPRIKEN Center for Emergent Matter Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New 1,5-diarylpyrazole oxime hybrid derivatives (scaffolds

Indexed as

Antineoplastic AgentsOximesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorErbB ReceptorsHeLa CellsHumansMolecular Docking SimulationMolecular StructureProtein Kinase InhibitorsSorafenibStructure-Activity RelationshipAntineoplastic AgentsEGFR protein, humanErbB ReceptorsOximesProtein Kinase InhibitorsSorafenibanti-proliferativedocking simulationEGFRJNK-2pyrazole

Identifiers

PMID37764297
PMCPMC10537604
OpenAlexW4386602333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.