Evidence map›Paper›PMID 37764289›Full record

ArticleMolecules (Basel, Switzerland)2023

In-Depth Analysis of the Mechanism of Astaxanthin Succinate Diester in Reducing Ulcerative Colitis in C57BL/6J Mice Based on Microbiota Informatics.

Xing Qiao, Qun Gao, Lu Yang, Xiaoxu Wang, Zhigao Wang, Zhaojie Li, Jie Xu, Changhu Xue

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xing QiaoCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Qun GaoCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Lu YangCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Xiaoxu WangCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Zhigao WangCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Zhaojie LiCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Jie XuCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Changhu XueCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Ocean University of China · CN

Funding

the National Key R&D Program of China 2018YFC0311206
6 · The paper itself

Abstract

This paper aims to explore the effect and mechanism of water-soluble astaxanthin succinate diester (Asta-SD) on ulcerative colitis (UC) induced by dextran sodium sulfate in zebrafish and C57BL/6J mice. Asta-SD was synthesized with hydrophilic fatty acid succinic anhydride and the hydroxyl groups at the ends of F-Asta were synthesized by esterifying. Through the construction of a zebrafish intestinal inflammation model, it was found that Asta-SD could effectively reduce the levels of ROS and increase the number of healthy intestinal lysosomes in zebrafish. After continuous gavage of Asta-SD for seven days, the body weight, disease activity index, colonic length, colonic histopathology, expression of inflammatory factors, and intestinal flora of the mice were measured. The results showed that Asta-SD could significantly alleviate weight loss and colonic shrinkage, as well as reducing pro-inflammatory cytokines and recess injury in UC mice. The 16S rRNA gene sequencing showed that Asta-SD significantly increased the beneficial bacteria (

Indexed as

Colitis, UlcerativeMicrobiotaAnimalsMiceMice, Inbred C57BLRNA, Ribosomal, 16SSuccinatesSuccinic AcidXanthophyllsZebrafishastaxanthineRNA, Ribosomal, 16SSuccinatesSuccinic AcidXanthophyllsastaxanthin succinate diesterdextran sulfate sodium (DSS)intestinal microbiotapro-inflammatory cytokinesulcerative colitis

Identifiers

PMID37764289
PMCPMC10537600
OpenAlexW4386547134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.