Evidence map›Paper›PMID 37764267›Full record

ArticleMolecules (Basel, Switzerland)2023

5-Nitrofuran-Tagged Oxazolyl Pyrazolopiperidines: Synthesis and Activity against ESKAPE Pathogens.

Elizaveta Rogacheva, Lyudmila Kraeva, Alexey Lukin, Lyubov Vinogradova, Kristina Komarova, Mikhail Chudinov, Maxim Gureev, Evgeny Chupakhin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elizaveta RogachevaPasteur Institute of Epidemiology and Microbiology, Saint Petersburg 197101, Russia.
Lyudmila KraevaPasteur Institute of Epidemiology and Microbiology, Saint Petersburg 197101, Russia.ORCID 0000-0002-9115-3250
Alexey LukinLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.ORCID 0000-0001-6162-4851
Lyubov VinogradovaLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.
Kristina KomarovaLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.
Mikhail ChudinovLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.ORCID 0000-0001-9735-9690
Maxim GureevLaboratory of Bio- and Chemoinformatics, I. M. Sechenov First Moscow State Medical University, Moscow 119991, Russia.ORCID 0000-0002-0385-922X
Evgeny ChupakhinInstitute of Living Systems, Immanuel Kant Baltic Federal University, Kaliningrad 236041, Russia.ORCID 0000-0001-5284-4748

Funding

Ministry of Education and Science of Russia FSFZ-2023-0004
6 · The paper itself

Abstract

A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has been prepared in six stages with excellent regioselectivity. The testing of these compounds against pathogens of the ESKAPE panel showed a good activity of lead compound 1-(2-methoxyethyl)-5-(5-nitro-2-furoyl)-3-(1,3-oxazol-5-yl)-4,5,6,7-tetrahydro-1

Indexed as

NitrofuransNitrofurantoinPiperidinesPyrazolesStructure-Activity RelationshipNitrofuransNitrofurantoinPiperidinesPyrazolespyrazolopiperidine5-nitrofuran derivativesantibacterial testingESKAPE pathogensflexible dockingnitroreductasestrained ligand–protein interactionstetrahydropyrazolopyridine

Identifiers

PMID37764267
PMCPMC10537382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.