Evidence map›Paper›PMID 37764198›Full record

ArticleMicroorganisms2023

A Whole-Genome Sequencing-Based Approach for the Characterization of

Arcadia Del Rio, Valeria Fox, Narcisa Muresu, Illari Sechi, Andrea Cossu, Alessandra Palmieri, Rossana Scutari, Claudia Alteri, Giovanni Sotgiu, Paolo Castiglia and 1 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Clonal dissemination and plasmid plasticity of KPC-3-producing Klebsiella pneumoniae ST512 during a hospital outbreak in Spain.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. Antibiotic resistance inFrontiers in microbiology · 2026
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Arcadia Del RioDepartment of Biomedical Science, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-1343-986X
Valeria FoxDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy.
Narcisa MuresuDepartment of Humanities and Social Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-3847-870X
Illari SechiDepartment of Medicine, Surgery, and Pharmacy, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-7477-8320
Andrea CossuDepartment of Medicine, Surgery, and Pharmacy, University of Sassari, 07100 Sassari, Italy.
Alessandra PalmieriDepartment of Medicine, Surgery, and Pharmacy, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-9202-7889
Rossana ScutariDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy.
Claudia AlteriDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy.
Giovanni SotgiuClinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Medicine, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-1600-4474
Paolo CastigliaDepartment of Medicine, Surgery, and Pharmacy, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-0972-4828
Andrea PianaDepartment of Medicine, Surgery, and Pharmacy, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-6609-8886
University of Sassari · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhole-genome sequencing (WGS) provides important information for the characterization, surveillance, and monitoring of antimicrobial resistance (AMR) determinants, particularly in cases of multi- and extensively drug-resistant microorganisms. We reported the results of a WGS analysis carried out on carbapenemases-producing

methodsClinical, phenotypic, and genotypic data were collected for the AMR surveillance screening program of the University Hospital of Sassari (Italy) during 2020-2021. Genomic DNA was sequenced using the Illumina Nova Seq 6000 platform. Final assemblies were manually curated and carefully verified for the detection of antimicrobial resistance genes, porin mutations, and virulence factors. A phylogenetic analysis was performed using the maximum likelihood method.

resultsAll 17 strains analyzed belonged to ST512, and most of them carried the

conclusionWGS characterization revealed the presence of several antibiotic resistance determinants and porin mutations in highly resistant

Indexed as

carbapenemasesKlebsiella pneumoniaewhole-genome sequencingβ-lactam/β-lactamases inhibitors

Identifiers

PMID37764198
PMCPMC10535212
OpenAlexW4386879163

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.