ArticleMicroorganisms2023
Genetic Insights into Intestinal Microbiota and Risk of Infertility: A Mendelian Randomization Study.
Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Review of Mendelian randomization studies on common male-specific diseases.Frontiers in endocrinology · 2025Pooled it
- Gut Dysbiosis in Selected Gynecological Diseases Associated with Female Infertility: A Scoping Review.Journal of clinical medicine · 2026Review
- Causal Relationship Between Gut Microbiota and Female Infertility: A Bidirectional Mendelian Randomization Analysis.JBRA assisted reproduction · 2026Article
- Functional fiber supplementation improves reproductive performance in sows by reshaping gut microbial functions related to immunity and metabolic health.Frontiers in veterinary science · 2026Article
- The Impact of Lifestyle on Reproductive Health: Microbial Complexity, Hormonal Dysfunction, and Pregnancy Outcomes.International journal of molecular sciences · 2025Review
- How does gut microbiota affect the vaginitis axis? The mediating role of plasma metabolites.Microbiology spectrum · 2025Article
- Causal Impact of Immune Phenotypes on Herpes Zoster and Postherpetic Neuralgia: Insights from Mendelian Randomization Analysis.Clinical, cosmetic and investigational dermatology · 2025Article
- Review
- The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health.Microorganisms · 2024Review
- No evidence of genetic causation between iron and infertility: a Mendelian randomization study.Frontiers in nutrition · 2024Article
- Genetic insights into the gut microbiota, herpes zoster, and postherpetic neuralgia: a bidirectional two-sample Mendelian randomization study.Frontiers in genetics · 2024Article
- Role of the gut microbiota in the pathogenesis of endometriosis: a review.Frontiers in microbiology · 2024Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe interaction between intestinal microbiota and infertility is less researched. This study was performed to investigate the causal association between gut microbiota and infertility.
methodsIn this two-sample Mendelian randomization (MR) study, genetic variants of intestinal microbiota were obtained from the MiBioGen consortium, which included 18,340 individuals. Inverse variance weighting (IVW), MR-Egger, weighted median, maximum likelihood, MR Robust adjusted profile score, MR Pleiotropy residual sum, and outlier (MR-PRESSO) methods were used to explore the causal links between intestinal microbiota and infertility. The MR-Egger intercept term and the global test from the MR-PRESSO estimator were used to assess the horizontal pleiotropy. The Cochran Q test was applied to evaluate the heterogeneity of instrumental variables (IVs).
resultsAs indicated by the IVW estimator, significantly protective effects of the
conclusionsThis two-sample MR study revealed that genetically proxied intestinal microbiota had potentially causal effects on infertility. In all, the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.