Evidence map›Paper›PMID 37764094›Full record

ArticleMicroorganisms2023

Specific Oral Microbial Differences in Proteobacteria and Bacteroidetes Are Associated with Distinct Sites When Moving from Healthy Mucosa to Oral Dysplasia-A Microbiome and Gene Profiling Study and Focused Review.

Allan Radaic, Eliah R Shamir, Kyle Jones, Alessandro Villa, Nandita R Garud, Aaron D Tward, Pachiyappan Kamarajan, Yvonne L Kapila

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. [Effects and Mechanisms of Yangyin Yiqi Huoxue Formula on the Oral Microecology in Sjögren's Syndrome Model Mice].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Allan RadaicSchool of Dentistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.ORCID 0000-0002-0899-9061
Eliah R ShamirSchool of Medicine, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA.
Kyle JonesSchool of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA.
Alessandro VillaSchool of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA.
Nandita R GarudCollege of Life Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Aaron D TwardSchool of Medicine, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA.
Pachiyappan KamarajanSchool of Dentistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Yvonne L KapilaSchool of Dentistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
University of California, Los Angeles · USUniversity of California, San Francisco · USBaptist Hospital of Miami · US

Funding

Oral microbiome and inflammatory status in antimicrobially-treated oral cancer patientsR01CA269950 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne L Kapila, Sue S. Yom · 2022 to 2026
$3.1M
NCI NIH HHS R01 CA269950
6 · The paper itself

Abstract

Oral potentially malignant disorders (OPMDs) are a group of conditions that carry a risk of oral squamous cell carcinoma (OSCC) development. Recent studies indicate that periodontal disease-associated pathogenic bacteria may play a role in the transition from healthy mucosa to dysplasia and to OSCC. Yet, the microbial signatures associated with the transition from healthy mucosa to dysplasia have not been established. To characterize oral microbial signatures at these different sites, we performed a 16S sequencing analysis of both oral swab and formalin-fixed, paraffin-embedded tissue (FFPE) samples. We collected oral swabs from healthy mucosa (from healthy patients), histologically normal mucosa adjacent to dysplasia, and low-grade oral dysplasia. Additionally, FFPE samples from histologically normal mucosa adjacent to OSCC, plus low grade and high-grade oral dysplasia samples were also collected. The collected data demonstrate significant differences in the alpha and beta microbial diversities of different sites in oral mucosa, dysplasia, and OSCC, as well as increased dissimilarities within these sites. We found that the Proteobacteria phyla abundance increased, concurrent with a progressive decrease in the Firmicutes phyla abundance, as well as altered levels of

Indexed as

dysbiosisFirmicutesmicrobial signatureOEDOPMDoral canceroral epithelial dysplasiaoral microbiomeOSCCProteobacteria

Identifiers

PMID37764094
PMCPMC10534919
OpenAlexW4386496380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.