Evidence map›Paper›PMID 37763816›Full record

ArticleMicromachines2023

Microfluidic Microcirculation Mimetic for Exploring Biophysical Mechanisms of Chemotherapy-Induced Metastasis.

Ashley Abraham, Sukhman Virdi, Nick Herrero, Israel Bryant, Chisom Nwakama, Megha Jacob, Gargee Khaparde, Destiny Jordan, Mackenzie McCuddin, Spencer McKinley and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ashley AbrahamBiology Department, Creighton University, Omaha, NE 68178, USA.
Sukhman VirdiPhysics Department, Creighton University, Omaha, NE 68178, USA.
Nick HerreroBiology Department, Creighton University, Omaha, NE 68178, USA.
Israel BryantPhysics Department, Creighton University, Omaha, NE 68178, USA.
Chisom NwakamaChemistry Department, Creighton University, Omaha, NE 68178, USA.
Megha JacobBiology Department, Creighton University, Omaha, NE 68178, USA.
Gargee KhapardeBiology Department, Creighton University, Omaha, NE 68178, USA.
Destiny JordanBiology Department, Creighton University, Omaha, NE 68178, USA.
Mackenzie McCuddinBiology Department, Creighton University, Omaha, NE 68178, USA.
Spencer McKinleyBiology Department, Creighton University, Omaha, NE 68178, USA.
Adam TaylorBiology Department, Creighton University, Omaha, NE 68178, USA.
Conner PeeplesPhysics Department, Creighton University, Omaha, NE 68178, USA.
Andrew EkpenyongPhysics Department, Creighton University, Omaha, NE 68178, USA.ORCID 0000-0003-0191-8393

Funding

Creighton University College of Arts and Sciences, Startup Grant 240133
6 · The paper itself

Abstract

There is rapidly emerging evidence from pre-clinical studies, patient samples and patient subpopulations that certain chemotherapeutics inadvertently produce prometastatic effects. Prior to this, we showed that doxorubicin and daunorubicin stiffen cells before causing cell death, predisposing the cells to clogging and extravasation, the latter being a step in metastasis. Here, we investigate which other anti-cancer drugs might have similar prometastatic effects by altering the biophysical properties of cells. We treated myelogenous (K562) leukemic cancer cells with the drugs nocodazole and hydroxyurea and then measured their mechanical properties using a microfluidic microcirculation mimetic (MMM) device, which mimics aspects of blood circulation and enables the measurement of cell mechanical properties via transit times through the device. We also quantified the morphological properties of cells to explore biophysical mechanisms underlying the MMM results. Results from MMM measurements show that nocodazole- and hydroxyurea-treated K562 cells exhibit significantly altered transit times. Nocodazole caused a significant (

Indexed as

cancerchemotherapymechanical propertiesmetastasismicrocirculationmicrofluidicsphysics of cancertumor microenvironment

Identifiers

PMID37763816
PMCPMC10536821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.