Evidence map›Paper›PMID 37763304›Full record

ArticleLife (Basel, Switzerland)2023

Refining Clinical Quantification of Depth of Suppression in Amblyopia through Synoptophore Measurement.

Maureen D Plaumann, Krista L Roberts, Wei Wei, Chao Han, Teng Leng Ooi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maureen D PlaumannCollege of Optometry, The Ohio State University, Columbus, OH 43210, USA.
Krista L RobertsCollege of Optometry, The Ohio State University, Columbus, OH 43210, USA.
Wei WeiCollege of Optometry, The Ohio State University, Columbus, OH 43210, USA.
Chao HanCollege of Optometry, The Ohio State University, Columbus, OH 43210, USA.
Teng Leng OoiCollege of Optometry, The Ohio State University, Columbus, OH 43210, USA.
SUNY College of Optometry · USThe Ohio State University · US

Funding

Mid-level mechanisms of surface and binocular perceptionR01EY023561 · NEI · UNIVERSITY OF LOUISVILLE · PI HE, ZIJIANG · 2014 to 2018
$1.7M
Improving Binocular Vision Through Perceptual LearningR01EY023374 · NEI · SALUS UNIVERSITY · PI OOI, TENG LENG · 2014 to 2016
$998k
NEI NIH HHS EY023561 and EY023374NEI NIH HHS R01 EY023374NEI NIH HHS R01 EY023561
6 · The paper itself

Abstract

backgroundAmblyopia is associated with unbalanced suppression between the two eyes. Existing clinical measures of suppression, such as the Worth 4 Dot test, provide qualitative information about suppression but cannot precisely quantify it. The Synoptophore, a well-established instrument in binocular vision clinics, has historically been used to gauge suppression qualitatively as well but has the capability to quantify suppression. We extended the capability of the Synoptophore through the development of a systematic protocol of illumination manipulation to quantify suppression in amblyopia.

methodsTwenty-six previously treated adult amblyopes underwent our protocol on the Synoptophore to measure the illumination balance needed to obtain fusion responses. Separately, these same amblyopes were tested with Worth 4 Dot as it is classically performed in the United States, utilizing different test distances and room illuminations to qualify the suppression response.

resultsSmaller, more central targets revealed larger magnitudes of suppression for both the Synoptophore and Worth 4 Dot tests (Synoptophore: χ

conclusionsWe extended the utility of the Synoptophore by measuring its illuminance outputs and developing a suppression testing protocol that compared favorably with Worth 4 Dot (clinic standard) while improving upon the latter through more sensitive quantification of suppression.

Indexed as

amblyopiailluminancestereopsissuppressionSynoptophore

Identifiers

PMID37763304
PMCPMC10532546
OpenAlexW4386689468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.