Evidence map›Paper›PMID 37763256›Full record

ArticleLife (Basel, Switzerland)2023

Circuits and Biomarkers of the Central Nervous System Relating to Astronaut Performance: Summary Report for a NASA-Sponsored Technical Interchange Meeting.

Joshua S Alwood, Ajitkumar P Mulavara, Janani Iyer, Siddhita D Mhatre, Susanna Rosi, Mark Shelhamer, Catherine Davis, Christopher W Jones, Xiao Wen Mao, Rajeev I Desai and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 1 country.

Joshua S AlwoodNASA Ames Research Center, Moffett Field, CA 94035, USA.
Ajitkumar P MulavaraKBR, Houston, TX 77058, USA.
Janani IyerUniversities Space Research Association (USRA), Moffett Field, CA 94035, USA.
Siddhita D MhatreKBR, Houston, TX 77058, USA.
Susanna RosiDepartment of Physical Therapy & Rehabilitation Science, University of California, San Francisco, CA 94110, USA.
Mark ShelhamerDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21205, USA.
Catherine DavisDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD 20814, USA.ORCID 0000-0002-2591-6352
Christopher W JonesDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-8173-721X
Xiao Wen MaoDepartment of Basic Sciences, Division of Biomedical Engineering Sciences (BMES), Loma Linda University Health, Loma Linda, CA 92354, USA.ORCID 0000-0002-4508-8689
Rajeev I DesaiIntegrative Neurochemistry Laboratory, Behavioral Biology Program, McLean Hospital-Harvard Medical School, Belmont, MA 02478, USA.
Alexandra M WhitmireNASA Johnson Space Center, Houston, TX 77058, USA.
Thomas J WilliamsNASA Johnson Space Center, Houston, TX 77058, USA.
Johnson Space Center · USKBR (United States) · USAmes Research Center · USHarvard University · USJohns Hopkins University · USLoma Linda University · USUniformed Services University of the Health Sciences · USUniversities Space Research Association · USUniversity of California, San Francisco · USUniversity of Pennsylvania · US

Funding

NASA Human Research Program
6 · The paper itself

Abstract

Biomarkers, ranging from molecules to behavior, can be used to identify thresholds beyond which performance of mission tasks may be compromised and could potentially trigger the activation of countermeasures. Identification of homologous brain regions and/or neural circuits related to operational performance may allow for translational studies between species. Three discussion groups were directed to use operationally relevant performance tasks as a driver when identifying biomarkers and brain regions or circuits for selected constructs. Here we summarize small-group discussions in tables of circuits and biomarkers categorized by (a) sensorimotor, (b) behavioral medicine and (c) integrated approaches (e.g., physiological responses). In total, hundreds of biomarkers have been identified and are summarized herein by the respective group leads. We hope the meeting proceedings become a rich resource for NASA's Human Research Program (HRP) and the community of researchers.

Indexed as

astronautbehaviorbiomarkerbrain circuitCNScognitionperformance

Identifiers

PMID37763256
PMCPMC10532466
OpenAlexW4386371799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.