Evidence map›Paper›PMID 37763252›Full record

ArticleLife (Basel, Switzerland)2023

The Impact of Number of Medications on Falls in Aging Persons with Human Immunodeficiency Virus.

Leanne W Thai, Lucas Hill, Shannon Balcombe, Afsana Karim, Maile Young Karris

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Leanne W ThaiDepartment of Pharmacy, Scripps Mercy Hospital, San Diego, CA 92103, USA.
Lucas HillDepartment of Pharmacy, University of California San Diego, San Diego, CA 92103, USA.ORCID 0000-0002-5689-5865
Shannon BalcombeDepartment of Pharmacy, University of California San Diego, San Diego, CA 92103, USA.
Afsana KarimDepartment of Medicine, University of California San Diego, San Diego, CA 92103, USA.
Maile Young KarrisDepartment of Medicine, University of California San Diego, San Diego, CA 92103, USA.ORCID 0000-0001-5614-030X
University of California San Diego · USScripps Mercy Hospital · US

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN JANET LITTLE · 1994 to 2026
$78.4M
A Novel Wireless Ingestible Sensor System for Measurement of Medication Adherence in HIV Treatment and PreventionR01MH110057 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BENSON, CONSTANCE ANN, BROWNE, SARA H. · 2015 to 2019
$5.9M
Screening for atherosclerotic vascular disease in HIV-infected childrenR01HD083042 · NICHD · STELLENBOSCH UNIVERSITY · PI HAUBRICH, RICHARD H, INNES, STEVE · 2015 to 2019
$1.6M
NIAID NIH HHS P30 AI036214NICHD NIH HHS R01 HD083042NIMH NIH HHS R01 MH110057
6 · The paper itself

Abstract

We aimed to evaluate the impact of polypharmacy on the risk of having a fall in older persons with HIV (PWH). PWH at least 50 years of age who were seen at our institution from September 2012 to August 2017 were included. Unique participants were selected for either a case or control cohort depending on the presence of a documented fall during the study time period. Demographics, HIV-related measures, VACS score, number of medications, as well as the impact of taking benzodiazepines and opioids were compared between the two cohorts. Fall was documented for 637 patients compared to 1534 without a fall during the same time period. Multivariable logistic regression revealed that the total number of medications, having a higher VACS score, taking an opioid, being female sex assigned at birth, and having a lower nadir CD4 count were significantly associated with higher odds of having a fall. In this cohort of older PWH, taking a higher number of non-ARV medications significantly increased the odds of having a fall. In addition, taking an opioid resulted in the highest odds of having a fall. These results suggest the importance of deprescribing and addressing opioid use in reducing the risk of having a fall in older PWH.

Indexed as

agingfallsHIVpolypharmacy

Identifiers

PMID37763252
PMCPMC10533185
OpenAlexW4386332333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.