ArticleJournal of clinical medicine2023
The Worsening of Heart Failure with Reduced Ejection Fraction: The Impact of the Number of Hospital Admissions in a Cohort of Patients.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- The efficacy and safety of hydroxychloroquine in patients with chronic inflammatory cardiomyopathy: a multicenter randomized study (HYPIC trial).BMC medicine · 2025Trial
- Association between empagliflozin exposure and skeletal muscle degeneration in patients with heart failure.BMC cardiovascular disorders · 2026Observational
- Inflammatory Phenotypes and Biomarker Trajectories During Hospitalization for Acute Heart Failure.Biomedicines · 2026Article
- Prognostic Impact of Baseline Potassium Abnormalities in Patients with Heart Failure with Reduced Ejection Fraction: A Real-World Cohort Study.Medical sciences (Basel, Switzerland) · 2026Article
- Low T3 syndrome in heart failure: prevalence and its relationship with disease severity and ejection fraction.BMC cardiovascular disorders · 2026Observational
- Sacubitril/valsartan affects pulmonary arterial pressure in heart failure with preserved ejection fraction and pulmonary hypertension among PD patients.International urology and nephrology · 2025Article
- The impact of decreased left ventricular ejection fraction on neutrophil extracellular trap (NET) formation measured by citrullinated histone H3 (citH_3) concentration.Scientific reports · 2025Article
- Evidence-based medical therapies for acute heart failure in Cameroon: a retrospective analysis of prescription patterns at Laquintinie Hospital, Douala, 2022-2024.Scientific reports · 2025Article
- Prognostic impact of moderate to severe anemia associated with renal dysfunction in patients with heart failure.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWorsening heart failure (WFH) includes heart failure (HF) hospitalisation, representing a strong predictor of mortality in patients with heart failure with reduced ejection fraction (HFrEF). However, there is little evidence analysing the impact of the number of previous HF admissions. Our main objective was to analyse the clinical profile according to the number of previous admissions for HF and its prognostic impact in the medium and long term.
methodsA retrospective study of a cohort of patients with HFrEF, classified according to previous admissions: cohort-1 (0-1 previous admission) and cohort-2 (≥2 previous admissions). Clinical, echocardiographic and therapeutic variables were analysed, and the medium- and long-term impacts in terms of hospital readmissions and cardiovascular mortality were assessed. A total of 406 patients were analysed.
resultsThe mean age was 67.3 ± 12.6 years, with male predominance (73.9%). Some 88.9% (361 patients) were included in cohort-1, and 45 patients (11.1%) were included in cohort-2. Cohort-2 had a higher proportion of atrial fibrillation (49.9% vs. 73.3%;
conclusionsPatients with HFrEF and ≥2 previous admissions for HF have a higher proportion of comorbidities. These patients are associated with worse reverse remodelling and worse medium- and long-term prognoses from the early stages, wherein early identification is essential for close follow-up and optimal intensive treatment.
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