Evidence map›Paper›PMID 37763014›Full record

ReviewJournal of clinical medicine2023

Platelets and the Atherosclerotic Process: An Overview of New Markers of Platelet Activation and Reactivity, and Their Implications in Primary and Secondary Prevention.

Matteo Nardin, Monica Verdoia, Davide Cao, Simone Nardin, Elvin Kedhi, Gennaro Galasso, Arnoud W J van 't Hof, Gianluigi Condorelli, Giuseppe De Luca

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Matteo NardinDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy.ORCID 0000-0003-4668-6661
Monica VerdoiaDivision of Cardiology, Ospedale degli Infermi, ASL Biella, 13875 Biella, Italy.ORCID 0000-0001-6506-8397
Davide CaoDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy.
Simone NardinU.O. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.ORCID 0000-0001-6150-5895
Elvin KedhiDivision of Cardiology, Hopital Erasmus, Universitè Libre de Bruxelles, 1050 Bruxelles, Belgium.
Gennaro GalassoDivision of Cardiology, Ospedale Ruggi D'Aragona, Università di Salerno, 84084 Salerno, Italy.ORCID 0000-0002-7265-7613
Arnoud W J van 't HofDepartment of Cardiology, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands.
Gianluigi CondorelliDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy.
Giuseppe De LucaDivision of Cardiology, AOU "Policlinico G. Martino", Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.ORCID 0000-0001-6031-2899
Humanitas University · ITMaastricht University · NLOspedale Policlinico San Martino · ITOspedali Riuniti San Giovanni di Dio e Ruggi d'Aragona · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversité Libre de Bruxelles · BEUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The key role played by platelets in the atherosclerosis physiopathology, especially in the acute setting, is ascertained: they are the main actors during thrombus formation and, thus, one of the major investigated elements related to atherothrombotic process involving coronary arteries. Platelets have been studied from different points of view, according with the technology advances and the improvement in the hemostasis knowledge achieved in the last years. Morphology and reactivity constitute the first aspects investigated related to platelets with a significant body of evidence published linking a number of their values and markers to coronary artery disease and cardiovascular events. Recently, the impact of genetics on platelet activation has been explored with promising findings as additional instrument for patient risk stratification; however, this deserves further confirmations. Moreover, the interplay between immune system and platelets has been partially elucidated in the last years, providing intriguing elements that will be basic components for future research to better understand platelet regulation and improve cardiovascular outcome of patients.

Indexed as

atherosclerosisgeneticsimmunityplatelet function testplatelet reactivityplateletsprevention

Identifiers

PMID37763014
PMCPMC10531614
OpenAlexW4386933898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.