ReviewJournal of clinical medicine2023
REM-OSA as a Tool to Understand Both the Architecture of Sleep and Pathogenesis of Sleep Apnea-Literature Review.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Molecular Drivers of Cognitive Decline and Neuroprotection in Obstructive Sleep Apnea: A Narrative Review.Antioxidants (Basel, Switzerland) · 2026Review
- Outcome of Targeted Therapy for Obstructive Sleep Apnea in Children with Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).Children (Basel, Switzerland) · 2026Article
- Role of the Amygdala in the Complex Relationship Between Sleep and Anxiety.International journal of molecular sciences · 2026Review
- Development and Explainable Machine Learning Validation of a Novel Sleep Disturbance Ratio for Obstructive Sleep Apnea Severity Assessment.Diagnostics (Basel, Switzerland) · 2026Article
- Atlas and Updated Rules for the Scoring of Cyclic Alternating Pattern (CAP) in Human Sleep. A Consensus Report by a Taskforce of the European Sleep Research Society.Journal of sleep research · 2026Review
- Optimizing CPAP Adherence in Obstructive Sleep Apnea: A Narrative Review of Practical Strategies for Everyday Clinical Care.Healthcare (Basel, Switzerland) · 2026Review
- Reduced Serum Pannexin-1 Levels in Obstructive Sleep Apnea and Their Association with Nocturnal Hypoxemic Burden.Journal of clinical medicine · 2026Article
- Physiological phenotypes of obstructive sleep apnea identified by cluster analysis: Association with type 2 diabetes.Journal of diabetes investigation · 2026Article
- Short-term changes in respiratory muscle strength before and after sleep in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2026Article
- Obstructive sleep apnea's causal links to depression, well-being, and negative moods: a bidirectional mendelian randomized study.European archives of psychiatry and clinical neuroscience · 2026Article
- Review
- [Comparative study on clinical and polysomnographic characteristics between rapid eye movement and non-rapid eye movement obstructive sleep apnea].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Article
- [Analysis of Respiratory Variables During Sleep in a Sample of Women in Perimenopause: a retrospective cross-sectional study]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2025Article
- Psychological resilience as a mediator between sleep quality and mental well-being in patients with obstructive sleep apnea syndrome.BMC psychology · 2025Article
- Relationship Between Sleep and Immunology in Attention Deficit Hyperactivity Disorder.International journal of molecular sciences · 2025Review
- Orofacial pain/headache interlaced to insomnia, sleep apnea and periodic limb movement during sleep/restless leg syndrome: a critical and comprehensive review with insights into social determinants.Journal of oral & facial pain and headache · 2025Review
- REM-related obstructive sleep apnea: is it still an enigma or do we even care?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Exploring the link between comorbid insomnia and sleep apnea (COMISA) and erectile dysfunction: implications for male sexual health.Sexual medicine reviews · 2025Review
- The Influence of Serotonergic Signaling on Quality of Life, Depression, Insomnia, and Hypoxia in Obstructive Sleep Apnea Patients: Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Independent Association of Sleep Apnea-Specific Hypoxic Burden and Sleep Breathing Impairment Index with Thyroid Function in Obstructive Sleep Apnea: A Retrospective Study.Nature and science of sleep · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep is a complex physiological state, which can be divided into the non-rapid eye movement (NREM) phase and the REM phase. Both have some unique features and functions. This difference is best visible in electroencephalography recordings, respiratory system activity, arousals, autonomic nervous system activity, or metabolism. Obstructive sleep apnea (OSA) is a common condition characterized by recurrent episodes of pauses in breathing during sleep caused by blockage of the upper airways. This common condition has multifactorial ethiopathogenesis (e.g., anatomical predisposition, sex, obesity, and age). Within this heterogenous syndrome, some distinctive phenotypes sharing similar clinical features can be recognized, one of them being REM sleep predominant OSA (REM-OSA). The aim of this review was to describe the pathomechanism of REM-OSA phenotype, its specific clinical presentation, and its consequences. Available data suggest that in this group of patients, the severity of specific cardiovascular and metabolic complications is increased. Due to the impact of apneas and hypopneas predominance during REM sleep, patients are more prone to develop hypertension or glucose metabolism impairment. Additionally, due to the specific function of REM sleep, which is predominantly fragmented in the REM-OSA, this group presents with decreased neurocognitive performance, reflected in memory deterioration, and mood changes including depression. REM-OSA clinical diagnosis and treatment can alleviate these outcomes, surpassing the traditional treatment and focusing on a more personalized approach, such as using longer therapy of continuous positive airway pressure or oral appliance use.
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Registered trials
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