Evidence map›Paper›PMID 37762516›Full record

ArticleInternational journal of molecular sciences2023

The Anion Channel TMEM16a/Ano1 Modulates CFTR Activity, but Does Not Function as an Apical Anion Channel in Colonic Epithelium from Cystic Fibrosis Patients and Healthy Individuals.

Azam Salari, Renjie Xiu, Mahdi Amiri, Sophia Theres Pallenberg, Rainer Schreiber, Anna-Maria Dittrich, Burkhard Tümmler, Karl Kunzelmann, Ursula Seidler

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Ion transport and epithelial barrier dysfunction in experimental models of ulcerative colitis.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
  4. Review
  5. Article
  6. Cystic fibrosis.Nature reviews. Disease primers · 2024
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Azam SalariDepartment of Gastroenterology, Hannover Medical School, 30625 Hannover, Germany.
Renjie XiuDepartment of Gastroenterology, Hannover Medical School, 30625 Hannover, Germany.
Mahdi AmiriDepartment of Gastroenterology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0003-4775-9535
Sophia Theres PallenbergDepartment of Pediatric Pneumonology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-9948-7589
Rainer SchreiberInstitute of Physiology, University of Regensburg, 93040 Regensburg, Germany.ORCID 0000-0002-3974-5363
Anna-Maria DittrichDepartment of Pediatric Pneumonology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-9582-1025
Burkhard TümmlerDepartment of Pediatric Pneumonology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.
Karl KunzelmannInstitute of Physiology, University of Regensburg, 93040 Regensburg, Germany.ORCID 0000-0001-6222-4593
Ursula SeidlerDepartment of Gastroenterology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-9600-2769
Medizinische Hochschule Hannover · DEUniversity of Regensburg · DE

Funding

Deutsche Forschungsgemeinschaft Se 460/21-1Deutsche Forschungsgemeinschaft Se 460/22-1
6 · The paper itself

Abstract

Studies in human colonic cell lines and murine intestine suggest the presence of a Ca

Indexed as

Cystic FibrosisAnimalsAnionsAnoctamin-1Cystic Fibrosis Transmembrane Conductance RegulatorEpitheliumHumansMiceNeoplasm ProteinsUridine TriphosphateAnionsANO1 protein, humanAnoctamin-1CFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorNeoplasm ProteinsUridine Triphosphateanion conductancecalcium-activatedchloridecolonoidscystic fibrosisenteroidsfluid secretionhuman colonpurinergic receptorsrectal organoidsTMEM16aUssing chamber

Identifiers

PMID37762516
PMCPMC10531629
OpenAlexW4386836264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.