Evidence map›Paper›PMID 37762510›Full record

ArticleInternational journal of molecular sciences2023

Selective Block of Upregulated Kv1.3 Potassium Channels in ON-Bipolar Cells of the Blind Retina Enhances Optogenetically Restored Signaling.

Giulia Schilardi, Jakub Kralik, Sonja Kleinlogel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Giulia SchilardiInstitute of Physiology & Department of Biomedical Research (DBMR), Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0002-2121-9920
Jakub KralikInstitute of Physiology & Department of Biomedical Research (DBMR), Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0001-5216-9818
Sonja KleinlogelInstitute of Physiology & Department of Biomedical Research (DBMR), Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0001-8272-7833
University of Bern · CH

Funding

Swiss National Science Foundation 31003A_176065
6 · The paper itself

Abstract

Loss of photoreceptors in retinal degenerative diseases also impacts the inner retina: bipolar cell dendrites retract, neurons rewire, and protein expression changes. ON-bipolar cells (OBCs) represent an attractive target for optogenetic vision restoration. However, the above-described maladaptations may negatively impact the quality of restored vision. To investigate this question, we employed human post-mortem retinas and transgenic

Indexed as

BlindnessKv1.3 Potassium ChannelOptogeneticsRetinal Bipolar CellsRetinal DegenerationAgedAnimalsFemaleHumansMaleMiceMice, Inbred C57BLMice, TransgenicReceptors, Metabotropic GlutamateRetinaSignal TransductionKv1.3 Potassium Channelmetabotropic glutamate receptor 6Receptors, Metabotropic GlutamateKv1.3 channelmulti-electrode array recordingsON-bipolar cellsoptogenetic gene therapyOpto-mGluR6patch clampPsora-4retinal degenerationvision restoration

Identifiers

PMID37762510
PMCPMC10531754
OpenAlexW4386838398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.