Evidence map›Paper›PMID 37762490›Full record

ArticleInternational journal of molecular sciences2023

Anti-Tumor Immunogenicity of the Oncolytic Virus CF33-hNIS-antiPDL1 against Ex Vivo Peritoneal Cells from Gastric Cancer Patients.

Zhifang Zhang, Annie Yang, Shyambabu Chaurasiya, Anthony K Park, Sang-In Kim, Jianming Lu, Hannah Valencia, Yuman Fong, Yanghee Woo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zhifang ZhangDepartment of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.
Annie YangDepartment of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.
Shyambabu ChaurasiyaDepartment of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0002-9543-5458
Anthony K ParkCancer Immunotherapeutics Program, Beckman Research Institute of City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0001-7692-8874
Sang-In KimDepartment of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.
Jianming LuDepartment of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.
Hannah ValenciaDepartment of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.
Yuman FongDepartment of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.
Yanghee WooDepartment of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.
City Of Hope National Medical Center · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Commercialization of the Shutter-Speed Model for Dynamic MRI in Cancer DiagnosisR44CA180425 · NCI · IMBIO, LLC · PI KEITH, LAUREN · 2013 to 2016
$1.8M
NCI NIH HHS P30 CA033572NCI NIH HHS R44 CA180425United States Department of Defense CA180425
6 · The paper itself

Abstract

We studied the immunotherapeutic potential of CF33-hNIS-antiPDL1 oncolytic virus (OV) against gastric cancer with peritoneal metastasis (GCPM). We collected fresh malignant ascites (MA) or peritoneal washings (PW) during routine paracenteses and diagnostic laparoscopies from GC patients (n = 27). Cells were analyzed for cancer cell markers and T cells, or treated with PBS, CF33-GFP, or CF33-hNIS-antiPDL1 (MOI = 3). We analyzed infectivity, replication, cytotoxicity, CD107α upregulation of CD8

Indexed as

B7-H1 AntigenOncolytic VirotherapyOncolytic VirusesPeritoneal NeoplasmsStomach NeoplasmsAgedCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Line, TumorFemaleHumansMaleMiddle AgedB7-H1 AntigenCD274 protein, humandiagnostic laparoscopyex vivogastric cancermalignant ascitesoncolytic virotherapyperitoneal immune tumor microenvironmentperitoneal washings

Identifiers

PMID37762490
PMCPMC10532045
OpenAlexW4386814803

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.