Evidence map›Paper›PMID 37762397›Full record

ArticleInternational journal of molecular sciences2023

Chitosan Particles Complexed with CA5-HIF-1α Plasmids Increase Angiogenesis and Improve Wound Healing.

Louis J Born, Sameer Bengali, Angela Ting Wei Hsu, Sanaz Nourmohammadi Abadchi, Kai-Hua Chang, Frank Lay, Aerielle Matsangos, Christopher Johnson, Steven M Jay, John W Harmon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Emerging Nanotherapeutic Approaches for Diabetic Wound Healing.International journal of nanomedicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Louis J BornFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Sameer BengaliHendrix Burn and Wound Healing Laboratory, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Angela Ting Wei HsuHendrix Burn and Wound Healing Laboratory, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Sanaz Nourmohammadi AbadchiHendrix Burn and Wound Healing Laboratory, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kai-Hua ChangHendrix Burn and Wound Healing Laboratory, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Frank LayHendrix Burn and Wound Healing Laboratory, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Aerielle MatsangosHendrix Burn and Wound Healing Laboratory, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Christopher JohnsonHendrix Burn and Wound Healing Laboratory, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Steven M JayFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.ORCID 0000-0002-3827-5988
John W HarmonHendrix Burn and Wound Healing Laboratory, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Johns Hopkins University · USUniversity of Maryland, College Park · US

Funding

Characterization of the Cardiac Progenitor Cell Exosomes for Optimal TherapeuticsR01HL141922 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI KAUSHAL, SUNJAY · 2019 to 2022
$2.8M
Dementia Following Spinal Cord Injury: Mechanism and Therapeutic TargetingRF1NS110637 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI JAY, STEVEN MICHAEL, WU, JUNFANG · 2019 to 2019
$2.8M
Controlling Exosome Noncoding RNA Cargo for Enhanced Wound HealingR01HL141611 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI JAY, STEVEN MICHAEL · 2018 to 2022
$1.9M
Enabling exosome biomarker development via digitized single vesicle analysisR01GM130923 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI DEVOE, DON L, WHITE, IAN M · 2019 to 2022
$1.7M
Nanohydrocyclones for scalable extracellular vesicle purification and drug loadingR21HL159590 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI DEVOE, DON L, JAY, STEVEN MICHAEL · 2021 to 2022
$421k
NHLBI NIH HHS R01 HL141611NHLBI NIH HHS R01 HL141922NHLBI NIH HHS R21 HL159590NIGMS NIH HHS R01 GM130923NIH HHS GM130923NIH HHS HL141611NIH HHS HL141922NIH HHS HL159590NIH HHS NS110637NINDS NIH HHS RF1 NS110637
6 · The paper itself

Abstract

Wound therapies involving gene delivery to the skin have significant potential due to the advantage and ease of local treatment. However, choosing the appropriate vector to enable successful gene expression while also ensuring that the treatment's immediate material components are conducive to healing itself is critical. In this study, we utilized a particulate formulation of the polymer chitosan (chitosan particles, CPs) as a non-viral vector for the delivery of a plasmid encoding human CA5-HIF-1α, a degradation resistant form of HIF-1α, to enhance wound healing. We also compared the angiogenic potential of our treatment (HIF/CPs) to that of chitosan particles containing only the plasmid backbone (bb/CPs) and the chitosan particle vector alone (CPs). Our results indicate that chitosan particles exert angiogenic effects that are enhanced with the human CA5-HIF-1α-encoded plasmid. Moreover, HIF/CPs enhanced wound healing in diabetic db/db mice (

Indexed as

ChitosanHypoxia-Inducible Factor 1, alpha SubunitNeovascularization, PhysiologicPlasmidsWound HealingAngiogenesisAnimalsCarbonic Anhydrase IXGene Transfer TechniquesHumansMaleMiceCarbonic Anhydrase IXChitosanHIF1A protein, humanHypoxia-Inducible Factor 1, alpha Subunithypoxia-inducible factor-1αnanoparticlesnon-viral gene therapywound healing

Identifiers

PMID37762397
PMCPMC10531456
OpenAlexW4386785293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.