Evidence map›Paper›PMID 37762319›Full record

ArticleInternational journal of molecular sciences2023

Static Cold Storage with Mitochondria-Targeted Hydrogen Sulfide Donor Improves Renal Graft Function in an Ex Vivo Porcine Model of Controlled Donation-after-Cardiac-Death Kidney Transplantation.

George J Dugbartey, Smriti Juriasingani, Mahms Richard-Mohamed, Andrew Rasmussen, Max Levine, Winnie Liu, Aaron Haig, Matthew Whiteman, Jacqueline Arp, Patrick P W Luke and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

George J DugbarteyMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5C1, Canada.ORCID 0000-0001-8161-7202
Smriti JuriasinganiMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5C1, Canada.
Mahms Richard-MohamedMulti-Organ Transplant Program, London Health Sciences Center, Western University, London, ON N6A 5C1, Canada.ORCID 0000-0001-5920-6511
Andrew RasmussenDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5C1, Canada.
Max LevineDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5C1, Canada.
Winnie LiuDepartment of Pathology & Laboratory Medicine, Western University, London, ON N6A 5C1, Canada.
Aaron HaigDepartment of Pathology & Laboratory Medicine, Western University, London, ON N6A 5C1, Canada.
Matthew WhitemanSt. Luke's Campus, University of Exeter Medical School, Exeter EX1 2HZ, UK.
Jacqueline ArpMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5C1, Canada.
Patrick P W LukeMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5C1, Canada.
Alp SenerMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5C1, Canada.
Western University · CAUniversity of Exeter · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global donor kidney shortage crisis has necessitated the use of suboptimal kidneys from donors-after-cardiac-death (DCD). Using an ex vivo porcine model of DCD kidney transplantation, the present study investigates whether the addition of hydrogen sulfide donor, AP39, to University of Wisconsin (UW) solution improves graft quality. Renal pedicles of male pigs were clamped in situ for 30 min and the ureters and arteries were cannulated to mimic DCD. Next, both donor kidneys were nephrectomized and preserved by static cold storage in UW solution with or without AP39 (200 nM) at 4 °C for 4 h followed by reperfusion with stressed autologous blood for 4 h at 37 °C using ex vivo pulsatile perfusion apparatus. Urine and arterial blood samples were collected hourly during reperfusion. After 4 h of reperfusion, kidneys were collected for histopathological analysis. Compared to the UW-only group, UW+AP39 group showed significantly higher pO

Indexed as

Hydrogen SulfideKidney TransplantationAdenosineAllopurinolAnimalsCryopreservationGlutathioneHumansInsulinMaleMitochondriaOrgan Preservation SolutionsRaffinoseSwineAdenosineAllopurinolGlutathioneHydrogen SulfideInsulinOrgan Preservation SolutionsRaffinoseUniversity of Wisconsin-lactobionate solutionAP39donation-after-cardiac-death (DCD)ex vivo porcine modelhydrogen sulfide (H2S)ischemia-reperfusion injury (IRI)kidney transplantationstatic cold storage (SCS)

Identifiers

PMID37762319
PMCPMC10530714
OpenAlexW4386713449

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.