Investigating the Impact of Selective Modulators on the Renin-Angiotensin-Aldosterone System: Unraveling Their Off-Target Perturbations of Transmembrane Ionic Currents.

Open access · goldAbstract readReview

In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.6field-weighted citation impact, top 29% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Dexamethasone-mediated modulation of the renin-angiotensin system: current insights.Pharmacological reports : PR · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Te-Ling LuSchool of Pharmacy, China Medical University, Taichung 406040, Taiwan.ORCID 0000-0003-1408-6004

Sheng-Nan WuDepartment of Research and Education, An Nan Hospital, China Medical University, Tainan 709040, Taiwan.

China Medical University · TWNational Sun Yat-sen University · TW

Funding

An Nan Hospital, Tainan, Taiwan ANHRF111-10, ANHRF112-42 and ANAR-112-43

6 · The paper itself

Abstract

The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in maintaining various physiological processes in the body, including blood pressure regulation, electrolyte balance, and overall cardiovascular health. However, any compounds or drugs known to perturb the RAAS might have an additional impact on transmembrane ionic currents. In this retrospective review article, we aimed to present a selection of chemical compounds or medications that have long been recognized as interfering with the RAAS. It is noteworthy that these substances may also exhibit regulatory effects in different types of ionic currents. Apocynin, known to attenuate the angiotensin II-induced activation of epithelial Na

Indexed as

Angiotensin IIRenin-Angiotensin SystemBlood PressureGlucocorticoidsHumansReceptor, Endothelin ATelmisartanAngiotensin IIGlucocorticoidsReceptor, Endothelin ATelmisartanionic currentNa+ currentoff-target effectrenin–angiotensin–aldosterone systemsmall molecules

Identifiers

PMID37762309

DOI10.3390/ijms241814007

PMCPMC10530685

OpenAlexW4386629410

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.