Evidence map›Paper›PMID 37762278›Full record

ArticleInternational journal of molecular sciences2023

Amyloid-Beta Co-Pathology Is a Major Determinant of the Elevated Plasma GFAP Values in Amyotrophic Lateral Sclerosis.

Andrea Mastrangelo, Veria Vacchiano, Corrado Zenesini, Edoardo Ruggeri, Simone Baiardi, Arianna Cherici, Patrizia Avoni, Barbara Polischi, Francesca Santoro, Sabina Capellari and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Cognitive Impairment in Neurological Diseases.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Andrea MastrangeloDipartimento di Scienze Biomediche e Neuromotorie, Alma Mater Studiorum Università di Bologna, 40139 Bologna, Italy.
Veria VacchianoIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.ORCID 0000-0002-3607-2394
Corrado ZenesiniIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
Edoardo RuggeriIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
Simone BaiardiDipartimento di Scienze Biomediche e Neuromotorie, Alma Mater Studiorum Università di Bologna, 40139 Bologna, Italy.
Arianna ChericiIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
Patrizia AvoniDipartimento di Scienze Biomediche e Neuromotorie, Alma Mater Studiorum Università di Bologna, 40139 Bologna, Italy.
Barbara PolischiIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
Francesca SantoroIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
Sabina CapellariDipartimento di Scienze Biomediche e Neuromotorie, Alma Mater Studiorum Università di Bologna, 40139 Bologna, Italy.ORCID 0000-0003-1631-1439
Rocco LiguoriDipartimento di Scienze Biomediche e Neuromotorie, Alma Mater Studiorum Università di Bologna, 40139 Bologna, Italy.ORCID 0000-0002-1815-1013
Piero ParchiDipartimento di Scienze Biomediche e Neuromotorie, Alma Mater Studiorum Università di Bologna, 40139 Bologna, Italy.ORCID 0000-0002-9444-9524
Istituto delle Scienze Neurologiche di Bologna · ITUniversity of Bologna · IT

Funding

Ministero della Salute Ricerca Corrente#NextGenerationEU PE0000006
6 · The paper itself

Abstract

Recent studies reported increased plasma glial acidic fibrillary protein (GFAP) levels in amyotrophic lateral sclerosis (ALS) patients compared to controls. We expanded these findings in a larger cohort, including 156 ALS patients and 48 controls, and investigated the associations of plasma GFAP with clinical variables and other biofluid biomarkers. Plasma GFAP and Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers were assessed by the single molecule array and the Lumipulse platforms, respectively. In ALS patients, plasma GFAP was higher than in controls (

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyotrophic Lateral SclerosisGlial Fibrillary Acidic ProteinAgedBiomarkersCase-Control StudiesFemaleHumansMaleMiddle Agedtau ProteinsAmyloid beta-PeptidesBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteintau ProteinsAlzheimer’s diseaseamyotrophic lateral sclerosisbiofluid biomarkersco-pathologyGFAPneurodegenerationneuropsychology

Identifiers

PMID37762278
PMCPMC10531493
OpenAlexW4386686646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.