Evidence map›Paper›PMID 37762254›Full record

ArticleInternational journal of molecular sciences2023

Production of Recombinant Zika Virus Envelope Protein by Airlift Bioreactor as a New Subunit Vaccine Platform.

Hernan H M da Costa, Monica Bielavsky, Diego J B Orts, Sergio Araujo, Patrícia P Adriani, Juliana S Nogueira, Renato M Astray, Ramendra P Pandey, Marcelo Lancellotti, Jair P Cunha-Junior and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. NovelPathogens (Basel, Switzerland) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Hernan H M da CostaImmunology Center, Adolfo Lutz Institute, São Paulo 01246-902, Brazil.ORCID 0000-0001-8972-749X
Monica BielavskyImmunology Center, Adolfo Lutz Institute, São Paulo 01246-902, Brazil.
Diego J B OrtsImmunology Center, Adolfo Lutz Institute, São Paulo 01246-902, Brazil.ORCID 0000-0003-4209-9005
Sergio AraujoImmunology Center, Adolfo Lutz Institute, São Paulo 01246-902, Brazil.
Patrícia P AdrianiSkinzymes Biotechnology Ltd., São Paulo 05441-040, Brazil.
Juliana S NogueiraVirology Center, Adolfo Lutz Institute, São Paulo 01246-902, Brazil.
Renato M AstrayInterunits Graduate Program in Biotechnology, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-6983-5298
Ramendra P PandeySchool of Health Sciences and Technology, UPES University, Dehradun 248007, Uttarakhand, India.ORCID 0000-0002-5196-6468
Marcelo LancellottiFaculty of Pharmaceutical Sciences-FCF, University of Campinas-UNICAMP, Campinas 13083-871, Brazil.
Jair P Cunha-JuniorLaboratory of Immunochemistry and Immunotechnology, Department of Immunology, Federal University of Uberlândia, Uberlândia 38405-317, Brazil.
Carlos R PrudencioImmunology Center, Adolfo Lutz Institute, São Paulo 01246-902, Brazil.ORCID 0000-0001-7701-0707
Instituto Adolfo Lutz · BRUniversidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Uberlândia · BRUniversity of Petroleum and Energy Studies · IN

Funding

Coordination for the Improvement of Higher Education Personnel 88881.130804/2016-01Coordination for the Improvement of Higher Education Personnel 88887.703323/2022-00National Council for Scientific and Technological Development 130843/2020-2National Council for Scientific and Technological Development 440812/2016-0São Paulo Research Foundation 2017/50333-7São Paulo Research Foundation 2022/07256-0Special Health Fund for Mass Immunization and Disease Control of the State Department of Health of the State of São Paulo 032/2021
6 · The paper itself

Abstract

The Zika Virus (ZIKV) is an emerging arbovirus of great public health concern, particularly in the Americas after its last outbreak in 2015. There are still major challenges regarding disease control, and there is no ZIKV vaccine currently approved for human use. Among many different vaccine platforms currently under study, the recombinant envelope protein from Zika Virus (rEZIKV) constitutes an alternative option for vaccine development and has great potential for monitoring ZIKV infection and antibody response. This study describes a method to obtain a bioactive and functional rEZIKV using an

Indexed as

Viral VaccinesZika VirusZika Virus InfectionAntibodies, NeutralizingAntibodies, ViralBioreactorsEscherichia coliHumansRecombinant ProteinsVaccines, SubunitViral Envelope ProteinsAntibodies, NeutralizingAntibodies, ViralRecombinant ProteinsVaccines, SubunitViral Envelope ProteinsViral Vaccinesairlift bioreactorenvelope proteinFPLCrecombinant proteinrEZIKVZika Virus

Identifiers

PMID37762254
PMCPMC10531330
OpenAlexW4386601816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.