Evidence map›Paper›PMID 37762135›Full record

ArticleInternational journal of molecular sciences2023

Blood Immunophenotypes of Idiopathic Pulmonary Fibrosis: Relationship with Disease Severity and Progression.

Nuria Mendoza, Sandra Casas-Recasens, Núria Olvera, Fernanda Hernandez-Gonzalez, Tamara Cruz, Núria Albacar, Xavier Alsina-Restoy, Alejandro Frino-Garcia, Gemma López-Saiz, Lucas Robres and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Immunosenescence in Idiopathic Pulmonary Fibrosis.Journal of inflammation research · 2026
    Review
  4. T Regulatory Mechanisms in Airway and Interstitial Lung Disease.Seminars in respiratory and critical care medicine · 2025
    Review
  5. Article
  6. Article
  7. CD4Frontiers in immunology · 2025
    Review
  8. Article
  9. Review
  10. PD-1Respiratory research · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Nuria MendozaInstitut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Sandra Casas-RecasensInstitut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Núria OlveraInstitut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Fernanda Hernandez-GonzalezInstitut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Tamara CruzInstitut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0000-0002-6362-6348
Núria AlbacarInstitut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Xavier Alsina-RestoyRespiratory Institute, Clinic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-5536-6099
Alejandro Frino-GarciaRespiratory Institute, Clinic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-4426-5313
Gemma López-SaizRespiratory Institute, Clinic Barcelona, 08036 Barcelona, Spain.
Lucas RobresCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain.
Mauricio RojasDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Alvar AgustíInstitut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Jacobo SellarésInstitut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0000-0001-5403-5688
Rosa FanerInstitut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESHospital Clínic de Barcelona · ESBarcelona Supercomputing Center · ESThe Ohio State University Wexner Medical Center · US

Funding

Instituto de Salud Carlos III FIS19/01152Instituto de Salud Carlos III PI21/00735
6 · The paper itself

Abstract

(1) The role of the immune response in the pathogenesis of idiopathic pulmonary fibrosis (IPF) remains controversial. We hypothesized that peripheral blood immune phenotypes will be different in IPF patients and may relate to the disease severity and progression. (2) Whole blood flow cytometry staining was performed at diagnosis in 32 IPF patients, and in 32 age- and smoking-matched healthy controls. Thirty-one IPF patients were followed up for one year and categorized as stable or progressors based on lung function, deterioration and/or death. At 18-60 months, immunophenotypes were characterized again. (3) The main results showed that: (1) compared to matched controls, at diagnosis, patients with IPF showed more neutrophils, CD8

Indexed as

CD28 AntigensIdiopathic Pulmonary FibrosisDisease ProgressionFlow CytometryHumansPatient AcuityT-LymphocytesCD28 Antigensantifibrotic therapyimmunity and inflammationinterstitial lung diseases

Identifiers

PMID37762135
PMCPMC10531459
OpenAlexW4386559876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.