Evidence map›Paper›PMID 37762097›Full record

ArticleInternational journal of molecular sciences2023

Measuring Up: A Comparison of TapeStation 4200 and Bioanalyzer 2100 as Measurement Tools for RNA Quality in Postmortem Human Brain Samples.

Jessica E Walker, Javon C Oliver, Analisa M Stewart, Suet Theng Beh, Richard A Arce, Michael J Glass, Daisy E Vargas, Sanaria H Qiji, Anthony J Intorcia, Claryssa I Borja and 10 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. An analysis of RNA quality metrics in human brain tissue.Journal of neuropathology and experimental neurology · 2025
    Article
  9. Article
  10. Frontiers in microbiology · 2025
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Jessica E WalkerBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Javon C OliverBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Analisa M StewartBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Suet Theng BehBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Richard A ArceBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Michael J GlassBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Daisy E VargasBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Sanaria H QijiBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Anthony J IntorciaBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Claryssa I BorjaBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Madison P ClineBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Spencer J HemmingsenBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Addison N KruppBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Rylee D McHattieBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Monica R MarinerBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Ileana LorenziniBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Sidra AslamBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Cecilia TremblayBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Thomas G BeachBanner Sun Health Research Institute, Sun City, AZ 85351, USA.
Geidy E SerranoBanner Sun Health Research Institute, Sun City, AZ 85351, USA.

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI GONZALEZ HERNANDEZ, GRACIELA · 2001 to 2020
$32.5M
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI HEATHER Allyson BIMONTE-NELSON · 2021 to 2026
$24.9M
National Brain and Tissue Resource for Parkinson's Disease and Related DisordersU24NS072026 · NINDS · BANNER SUN HEALTH RESEARCH INSTITUTE · PI BEACH, THOMAS G · 2011 to 2015
$7.8M
NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG072980NINDS NIH HHS U24 NS072026
6 · The paper itself

Abstract

The determination of RNA integrity is a critical quality assessment tool for gene expression studies where the experiment's success is highly dependent on the sample quality. Since its introduction in 1999, the gold standard in the scientific community has been the Agilent 2100 Bioanalyzer's RNA integrity number (RIN), which uses a 1-10 value system, from 1 being the most degraded, to 10 being the most intact. In 2015, Agilent launched 4200 TapeStation's RIN equivalent, and reported a strong correlation of r

Indexed as

BenchmarkingBrainHumansRNARNA2100 Bioanalyzer4200 TapeStationDV200RNA integrity numbersequencing

Identifiers

PMID37762097
PMCPMC10531353

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.