Observational studyInternational journal of molecular sciences2023
Oral Iron Absorption of Ferric Citrate Hydrate and Hepcidin-25 in Hemodialysis Patients: A Prospective, Multicenter, Observational Riona-Oral Iron Absorption Trial.
Observational study in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 4 citations in OpenAlex.
- Associations of Mean Corpuscular Hemoglobin with Survival and Cardiovascular Outcomes Among Patients with Hemodialysis in Japan Based on Real-World Data.Advances in therapy · 2026Article
- Predicting anemia treatment outcomes in maintenance hemodialysis patients using multiple machine learning models.BMC medical informatics and decision making · 2026Article
- Research Progress on Ferroptosis Regulation of Female Reproduction.Biological trace element research · 2026Review
- Study on the Threshold of Serum Ferritin Required for Erythropoiesis and Iron Sufficiency in Hemodialysis Patients.International journal of molecular sciences · 2026Article
- Association between serum hepcidin-25 levels and hyporesponsiveness to erythropoiesis-stimulating agents in Japanese patients receiving hemodialysis: a cross-sectional study.Clinical and experimental nephrology · 2026Observational
- A Prospective Clinical Study of Ferric Citrate Hydrate for Chronic Heart Failure with Iron Deficiency Anemia.Life (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
46 authors at 15 institutions in 1 country.
Funding
Abstract
Oral ferric citrate hydrate (FCH) is effective for iron deficiencies in hemodialysis patients; however, how iron balance in the body affects iron absorption in the intestinal tract remains unclear. This prospective observational study (Riona-Oral Iron Absorption Trial, R-OIAT, UMIN 000031406) was conducted at 42 hemodialysis centers in Japan, wherein 268 hemodialysis patients without inflammation were enrolled and treated with a fixed amount of FCH for 6 months. We assessed the predictive value of hepcidin-25 for iron absorption and iron shift between ferritin (FTN) and red blood cells (RBCs) following FCH therapy. Serum iron changes at 2 h (ΔFe2h) after FCH ingestion were evaluated as iron absorption. The primary outcome was the quantitative delineation of iron variables with respect to ΔFe2h, and the secondary outcome was the description of the predictors of the body's iron balance. Generalized estimating equations (GEEs) were used to identify the determinants of iron absorption during each phase of FCH treatment. ΔFe2h increased when hepcidin-25 and TSAT decreased (-0.459, -0.643 to -0.276,
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Registered trials
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