Evidence map›Paper›PMID 37762082›Full record

ArticleInternational journal of molecular sciences2023

USP7 Inhibition Suppresses Neuroblastoma Growth via Induction of p53-Mediated Apoptosis and EZH2 and N-Myc Downregulation.

Christophe Le Clorennec, Karen Lee, Yuchen Huo, Peter E Zage

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

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  11. Cancer: A Multifaceted Enemy and the Precision Oncology Response.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Christophe Le ClorennecDepartment of Pediatrics, Division of Hematology-Oncology, University of California San Diego, La Jolla, CA 92093, USA.
Karen LeeDepartment of Pediatrics, Division of Hematology-Oncology, University of California San Diego, La Jolla, CA 92093, USA.
Yuchen HuoDepartment of Pediatrics, Division of Hematology-Oncology, University of California San Diego, La Jolla, CA 92093, USA.
Peter E ZageDepartment of Pediatrics, Division of Hematology-Oncology, University of California San Diego, La Jolla, CA 92093, USA.
University of California, San Diego · USCenter for Cancer and Blood Disorders · USRady Children's Hospital-San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma (NB) is a pediatric malignancy originating from neural crest cells of the sympathetic nervous system that accounts for 15% of all pediatric cancer deaths. Despite advances in treatment, high-risk NB remains difficult to cure, highlighting the need for novel therapeutic approaches. Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays a critical role in tumor suppression and DNA repair, and

Indexed as

NeuroblastomaTumor Suppressor Protein p53ApoptosisChildDown-RegulationEnhancer of Zeste Homolog 2 ProteinHumansN-Myc Proto-Oncogene ProteinUbiquitin-Specific Peptidase 7Enhancer of Zeste Homolog 2 ProteinEZH2 protein, humanMYCN protein, humanN-Myc Proto-Oncogene ProteinTP53 protein, humanTumor Suppressor Protein p53Ubiquitin-Specific Peptidase 7USP7 protein, humandeubiquitinaseEZH2MDM2neuroblastomaN-Mycp53ubiquitinationUSP7 inhibitor

Identifiers

PMID37762082
PMCPMC10531325
OpenAlexW4386526563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.