Evidence map›Paper›PMID 37761946›Full record

ArticleGenes2023

Genes Involved in DNA Damage Cell Pathways and Health of the Oldest-Old (85+).

Maja Šetinc, Matea Zajc Petranović, Goran Slivšek, Sandra Mijač, Željka Celinščak, Anita Stojanović Marković, Vesna Bišof, Marijana Peričić Salihović, Tatjana Škarić-Jurić

Open access · goldAbstract read
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maja ŠetincInstitute for Anthropological Research, 10000 Zagreb, Croatia.ORCID 0000-0002-8641-5391
Matea Zajc PetranovićInstitute for Anthropological Research, 10000 Zagreb, Croatia.ORCID 0000-0002-8960-4446
Goran SlivšekFaculty of Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0002-7978-739X
Sandra MijačFaculty of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Željka CelinščakInstitute for Anthropological Research, 10000 Zagreb, Croatia.ORCID 0000-0002-1390-9614
Anita Stojanović MarkovićInstitute for Anthropological Research, 10000 Zagreb, Croatia.ORCID 0000-0001-5426-486X
Vesna BišofFaculty of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Marijana Peričić SalihovićInstitute for Anthropological Research, 10000 Zagreb, Croatia.
Tatjana Škarić-JurićInstitute for Anthropological Research, 10000 Zagreb, Croatia.ORCID 0000-0003-3708-6170
Institute for Anthropological Research · HRUniversity of Zagreb · HR

Funding

Croatian Science Foundation DOK-2018-09-8382Croatian Science Foundation IP-2018-01-2497
6 · The paper itself

Abstract

Some sources report a connection of cellular senescence with chronic pathological conditions; however, the association between particular cellular processes and general health is rarely examined. This study aims to test the relationship of general health with DNA damage pathways that play a crucial role in senescence. The association of ten selected SNPs with subjective and objective general health and functional ability indicators has been tested in 314 oldest-old people from Croatia. Multivariate logistic regression was employed to simultaneously test the impact of variables potentially influencing targeted health and functional ability variables. The best model, explaining 37.1% of the variance, has six independent significant predictors of functional ability scores: rs16847897 in

Indexed as

DNA DamageLongevityAged, 80 and overCellular SenescenceCyclin-Dependent Kinase Inhibitor p15DNA RepairFemaleHumansMaleMRE11 Homologue ProteinPolymorphism, Single NucleotideTelomeraseCyclin-Dependent Kinase Inhibitor p15MRE11 Homologue ProteinMRE11 protein, humanTelomeraseageingCDKN2BCroatiaDNA damage repairfunctional abilityMRE11Aoldest-oldself-rated healthsingle nucleotide polymorphismsTERC

Identifiers

PMID37761946
PMCPMC10530973
OpenAlexW4386814822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.