Evidence map›Paper›PMID 37761938›Full record

ArticleGenes2023

Polymorphisms within the SARS-CoV-2 Human Receptor Genes Associate with Variable Disease Outcomes across Ethnicities.

Theolan Adimulam, Thilona Arumugam, Anushka Naidoo, Kogieleum Naidoo, Veron Ramsuran

Open access · goldAbstract read
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Theolan AdimulamSchool of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.ORCID 0000-0002-7304-064X
Thilona ArumugamSchool of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.
Anushka NaidooCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban 4041, South Africa.
Kogieleum NaidooCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban 4041, South Africa.
Veron RamsuranSchool of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.ORCID 0000-0003-1590-9893
Centre for the AIDS Programme of Research in South Africa · ZAUniversity of KwaZulu-Natal · ZASouth African Medical Research Council · ZA

Funding

Second Generation InSTIs for the Treatment of HIV-1 in patients with TB co-infection on Rifampicin-based Treatment in KwaZulu Natal, South AfricaR01AI152142 · NIAID · CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA · PI DOOLEY, KELLY E., NAIDOO, ANUSHKA · 2020 to 2024
$2.9M
Dolutegravir for the treatment of HIV in patients with Tuberculosis in KwaZulu-Natal South AfricaK43TW011437 · FIC · CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA · PI NAIDOO, ANUSHKA · 2019 to 2023
$616k
FIC NIH HHS K43 TW011437Medical Research Council MC_PC_16022NIAID NIH HHS R01 AI152142
6 · The paper itself

Abstract

The contribution of human genes to the variability of disease outcomes has been shown to be important across infectious diseases. Studies have shown mutations within specific human genes are associated with variable COVID-19 outcomes. We focused on the SARS-CoV-2 receptors/co-receptors to identify the role of specific polymorphisms within

Indexed as

COVID-19SARS-CoV-2Angiotensin-Converting Enzyme 2EthnicityHumansPeptidyl-Dipeptidase ASouth AfricaAngiotensin-Converting Enzyme 2Peptidyl-Dipeptidase AACE2CD147COVID-19disease severityNRP1SARS-CoV-2 viral loadSNPTMPRSS2

Identifiers

PMID37761938
PMCPMC10531089
OpenAlexW4386744544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.