Evidence map›Paper›PMID 37761922›Full record

ArticleGenes2023

Clinical Factors Predicting Multiple Endocrine Neoplasia Type 1 and Type 4 in Patients with Neuroendocrine Tumors.

Antongiulio Faggiano, Beatrice Fazzalari, Nevena Mikovic, Flaminia Russo, Virginia Zamponi, Rossella Mazzilli, Vito Guarnieri, Maria Piane, Vincenzo Visco, Simona Petrucci

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Antongiulio FaggianoEndocrinology Unit, Sant'Andrea Hospital, ENETS Center of Excellence, 00189 Rome, Italy.ORCID 0000-0002-9324-3946
Beatrice FazzalariEndocrinology Unit, Sant'Andrea Hospital, ENETS Center of Excellence, 00189 Rome, Italy.
Nevena MikovicEndocrinology Unit, Sant'Andrea Hospital, ENETS Center of Excellence, 00189 Rome, Italy.
Flaminia RussoEndocrinology Unit, Sant'Andrea Hospital, ENETS Center of Excellence, 00189 Rome, Italy.
Virginia ZamponiEndocrinology Unit, Sant'Andrea Hospital, ENETS Center of Excellence, 00189 Rome, Italy.
Rossella MazzilliEndocrinology Unit, Sant'Andrea Hospital, ENETS Center of Excellence, 00189 Rome, Italy.
Vito GuarnieriDivision of Medical Genetics, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 Foggia, Italy.
Maria PianeDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0001-8569-247X
Vincenzo ViscoDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0001-5067-3121
Simona PetrucciDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy.
CTO Andrea Alesini · ITCasa Sollievo della Sofferenza · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to evaluate the predictive role of specific clinical factors for the diagnosis of Multiple Endocrine Neoplasia type-1 (MEN1) and type-4 (MEN4) in patients with an initial diagnosis of gastrointestinal, bronchial, or thymic neuroendocrine tumor (NET).

methodsPatients referred to the NET Unit between June 2021 and December 2022 with a diagnosis of NET and at least one clinical criterion of suspicion for MEN1 and MEN4 underwent molecular analysis of the

resultsA total of 22 patients were studied. In 18 patients (81.8%), the first-level genetic test was negative (Group A), while four patients (25%) were positive for

conclusionThese preliminary data show that a diagnosis of NET in patients with a negative family history is suggestive of MEN1 in the presence of ≥three positive phenotypic criteria, including early age, multifocality, multiple MEN-associated manifestations, and endocrine syndromes. This indication may allow optimization of the diagnosis of MEN in patients with NET.

Indexed as

Multiple Endocrine Neoplasia Type 1Neuroendocrine TumorsPituitary NeoplasmsAdultGastrointestinal TractGenetic TestingHumansgenetic testmultiple endocrine neoplasia type 1multiple endocrine neoplasia type 4neuroendocrine tumorsphenocopiespredictive factors

Identifiers

PMID37761922
PMCPMC10531237
OpenAlexW4386602642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.