Evidence map›Paper›PMID 37761892›Full record

ArticleGenes2023

Integrative Analysis Unveils the Correlation of Aminoacyl-tRNA Biosynthesis Metabolites with the Methylation of the

Sangeetha Vishweswaraiah, Ali Yilmaz, Nazia Saiyed, Abdullah Khalid, Purvesh R Koladiya, Xiaobei Pan, Shirin Macias, Andrew C Robinson, David Mann, Brian D Green and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Sangeetha VishweswaraiahDepartment of Obstetrics and Gynecology, Corewell Health William Beaumont University Hospital, 3601 W. 13 Mile Road, Royal Oak, MI 48073, USA.
Ali YilmazMetabolomics Department, Corewell Health Research Institute, 3811 W. 13 Mile Road, Royal Oak, MI 48073, USA.
Nazia SaiyedMetabolomics Department, Corewell Health Research Institute, 3811 W. 13 Mile Road, Royal Oak, MI 48073, USA.
Abdullah KhalidMetabolomics Department, Corewell Health Research Institute, 3811 W. 13 Mile Road, Royal Oak, MI 48073, USA.
Purvesh R KoladiyaMetabolomics Department, Corewell Health Research Institute, 3811 W. 13 Mile Road, Royal Oak, MI 48073, USA.
Xiaobei PanAdvanced Asset Technology Centre, Institute for Global Food Security, Queen's University Belfast, Belfast BT9 5DL, UK.
Shirin MaciasAdvanced Asset Technology Centre, Institute for Global Food Security, Queen's University Belfast, Belfast BT9 5DL, UK.
Andrew C RobinsonFaculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience, The University of Manchester, Salford Royal Hospital, Salford M6 8HD, UK.ORCID 0000-0003-2208-7728
David MannFaculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience, The University of Manchester, Salford Royal Hospital, Salford M6 8HD, UK.
Brian D GreenAdvanced Asset Technology Centre, Institute for Global Food Security, Queen's University Belfast, Belfast BT9 5DL, UK.ORCID 0000-0003-3331-0032
Ieva KerševičiūteVUGENE, LLC, 625 Kenmoor Ave Suite 301 PMB 96578, Grand Rapids, MI 49546, USA.
Juozas GordevičiusVUGENE, LLC, 625 Kenmoor Ave Suite 301 PMB 96578, Grand Rapids, MI 49546, USA.
Uppala RadhakrishnaDepartment of Obstetrics and Gynecology, Corewell Health William Beaumont University Hospital, 3601 W. 13 Mile Road, Royal Oak, MI 48073, USA.ORCID 0000-0002-6617-5634
Stewart F GrahamDepartment of Obstetrics and Gynecology, Corewell Health William Beaumont University Hospital, 3601 W. 13 Mile Road, Royal Oak, MI 48073, USA.ORCID 0000-0003-1001-0002
Queen's University Belfast · GBBeaumont Hospital, Royal Oak · USUniversity of Manchester · GBOakland University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of environmental factors on epigenetic changes is well established, and cellular function is determined not only by the genome but also by interacting partners such as metabolites. Given the significant impact of metabolism on disease progression, exploring the interaction between the metabolome and epigenome may offer new insights into Huntington's disease (HD) diagnosis and treatment. Using fourteen post-mortem HD cases and fourteen control subjects, we performed metabolomic profiling of human postmortem brain tissue (striatum and frontal lobe), and we performed DNA methylome profiling using the same frontal lobe tissue. Along with finding several perturbed metabolites and differentially methylated loci, Aminoacyl-tRNA biosynthesis (adj

Indexed as

Amino Acyl-tRNA SynthetasesHuntington DiseaseBrainHumansMetabolomeMethylationRNA, TransferAmino Acyl-tRNA SynthetasesO-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase, humanRNA, Transferbrainepigeneticsepi-metabolomicsHuntington’s diseaseintegrative omicsmetabolomics

Identifiers

PMID37761892
PMCPMC10530570
OpenAlexW4386420587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.