Evidence map›Paper›PMID 37761861›Full record

ArticleGenes2023

Gene Polymorphisms of Epithelial Cell-Derived Alarmins and Their Effects on Protein Levels and Disease Severity in Patients with COVID-19.

Maral Ranjbar, Ruth P Cusack, Christiane E Whetstone, Shiraz Nawaz, Christopher Khoury, Jennifer Wattie, Lesley Wiltshire, Jennifer Le Roux, Eric Cheng, Thivya Srinathan and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Maral RanjbarDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON L8N 3Z5, Canada.ORCID 0000-0003-2055-1013
Ruth P CusackDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Christiane E WhetstoneDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Shiraz NawazDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Christopher KhouryDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON L8N 3Z5, Canada.ORCID 0000-0002-0322-0231
Jennifer WattieDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Lesley WiltshireDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Jennifer Le RouxHamilton Health Sciences, Hamilton, ON L8N 3Z5, Canada.
Eric ChengSt. Joseph's Healthcare Hamilton, Hamilton, ON L8N 4A6, Canada.
Thivya SrinathanSt. Joseph's Healthcare Hamilton, Hamilton, ON L8N 4A6, Canada.
Terence HoDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Roma SehmiDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON L8N 3Z5, Canada.ORCID 0000-0003-0968-6304
MyLinh DuongDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Gail M GauvreauDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON L8N 3Z5, Canada.
McMaster University · CASt. Joseph’s Healthcare Hamilton · CAHamilton Health Sciences · CAPopulation Health Research Institute · CA

Funding

AstraZeneca (Canada) ESR20-20723Mitacs IT22844
6 · The paper itself

Abstract

backgroundThe immune response in COVID-19 is characterized by the release of alarmin cytokines, which play crucial roles in immune activation and inflammation. The interplay between these cytokines and genetic variations may influence disease severity and outcomes, while sex differences might further contribute to variations in the immune response.

methodsWe measured the levels of alarmin cytokines in a cohort of COVID-19 and non-COVID-19 patients using a sensitive Meso Scale Discovery system. Additionally, we conducted an SNP analysis to identify genetic variations within the

resultsOur findings revealed elevated levels of IL-33 and IL-25 in COVID-19-positive patients compared to COVID-19-negative patients (

conclusionThe present study highlights the importance of alarmin cytokines and genetic variations in COVID-19 severity, providing valuable insights into personalized treatment approaches. Our results suggest that targeting alarmin cytokines may offer potential therapeutic benefits in managing COVID-19. Furthermore, the sex-specific effects of genetic variations emphasize the need to consider individual genetic profiles and sex differences when designing targeted interventions.

Indexed as

AlarminsCOVID-19CytokinesInterleukin-33Polymorphism, Single NucleotideAdultAgedEpithelial CellsFemaleHumansInterleukin-17MaleMiddle AgedSARS-CoV-2Severity of Illness IndexThymic Stromal LymphopoietinAlarminsCytokinesIL25 protein, humanIL33 protein, humanInterleukin-17Interleukin-33Thymic Stromal LymphopoietinTSLP protein, humanalarminsCOVID-19severitysex specificsingle nucleotide polymorphisms

Identifiers

PMID37761861
PMCPMC10530834
OpenAlexW4386251097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.