Evidence map›Paper›PMID 37761842›Full record

ArticleGenes2023

Behavioral and Cognitive Performance Following Exposure to Second-Hand Smoke (SHS) from Tobacco Products Associated with Oxidative-Stress-Induced DNA Damage and Repair and Disruption of the Gut Microbiome.

Jacob Raber, Keaton Stagaman, Kristin D Kasschau, Conor Davenport, Leilani Lopes, Dennis Nguyen, Eileen Ruth Torres, Thomas J Sharpton, Glen Kisby

Open access · goldAbstract read
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Novel Techniques for Mapping DNA Damage and Repair in the Brain.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jacob RaberDepartment of Behavioral Neuroscience, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.ORCID 0000-0002-9861-9893
Keaton StagamanDepartment of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Kristin D KasschauDepartment of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Conor DavenportDepartment of Basic Medical Sciences, Western University of Health Sciences, College of Osteopathic Medicine of the Pacific Northwest, Lebanon, OR 97355, USA.ORCID 0000-0003-1837-5313
Leilani LopesDepartment of Basic Medical Sciences, Western University of Health Sciences, College of Osteopathic Medicine of the Pacific Northwest, Lebanon, OR 97355, USA.
Dennis NguyenDepartment of Basic Medical Sciences, Western University of Health Sciences, College of Osteopathic Medicine of the Pacific Northwest, Lebanon, OR 97355, USA.
Eileen Ruth TorresDepartment of Behavioral Neuroscience, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
Thomas J SharptonDepartment of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Glen KisbyDepartment of Basic Medical Sciences, Western University of Health Sciences, College of Osteopathic Medicine of the Pacific Northwest, Lebanon, OR 97355, USA.
Pacific Northwest University of Health Sciences · USOregon State University · US

Funding

Zebrafish Biomedical Research Facility CoreP30ES030287 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt · 2020 to 2026
$9.8M
Neuroscience of Aging, Neurodegeneration and Alzheimer’s DiseaseT32AG055378 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI JACOB RABER, HENRYK F URBANSKI · 2018 to 2026
$4.3M
Effects of apoE Isoform, Sex and Diet on Insulin Regulation in BrainRF1AG059088 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI BANKS, WILLIAM A, RABER, JACOB · 2018 to 2020
$2.5M
Impacts of Benzo[a]pyrene on Microbiome Development across Lifespan and Generations and the Behavioral ConsequencesR01ES030226 · NIEHS · OREGON STATE UNIVERSITY · PI SHARPTON, THOMAS JEFFERSON · 2019 to 2023
$2.1M
Skeletal Muscle Mitochondrial Adaptations to a Two-Year Caloric RestictionR01AG030226 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI SMITH, STEVEN RICHARD · 2008 to 2012
$1.6M
Role of human apolipoprotein E isoforms in long-term effects of West Nile Virus exposure on Alzheimer's disease-related behavioral alteration, cognitive injury, neuroinflammation, and neuropathologyR21AG079158 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI HIRSCH, ALEC J, RABER, JACOB · 2023 to 2024
$424k
Impact of Second-Hand Smoke on Brain Metabolism and Cognition in MiceR21ES027943 · NIEHS · OREGON HEALTH & SCIENCE UNIVERSITY · PI KISBY, GLEN E, RABER, JACOB · 2018 to 2019
$397k
NIA NIH HHS R01 AG030226NIA NIH HHS RF1 AG059088NIA NIH HHS T32 AG055378NIEHS NIH HHS P30 ES030287NIEHS NIH HHS R01 ES030226NIEHS NIH HHS R21 ES027943
6 · The paper itself

Abstract

Exposure to second-hand Smoke (SHS) remains prevalent. The underlying mechanisms of how SHS affects the brain require elucidation. We tested the hypothesis that SHS inhalation drives changes in the gut microbiome, impacting behavioral and cognitive performance as well as neuropathology in two-month-old wild-type (WT) mice and mice expressing wild-type human tau, a genetic model pertinent to Alzheimer's disease mice, following chronic SHS exposure (10 months to ~30 mg/m

Indexed as

Gastrointestinal MicrobiomeTobacco ProductsTobacco Smoke PollutionAnimalsCognitionDNA DamageHumansInfantMiceOxidative StressTobacco Smoke Pollution8-OH-dGAPE1cognitive performancegut microbiomenovel object recognitionp21second-hand smoke

Identifiers

PMID37761842
PMCPMC10531154
OpenAlexW4386221187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.