Evidence map›Paper›PMID 37761820›Full record

ArticleGenes2023

BRCA1 Promoter Hypermethylation in Malignant Breast Tumors and in the Histologically Normal Adjacent Tissues to the Tumors: Exploring Its Potential as a Biomarker and Its Clinical Significance in a Translational Approach.

Yassire Oubaddou, Mohamed Oukabli, Salma Fenniche, Abderrahim Elktaibi, Mohamed Reda Elochi, Abderrahmane Al Bouzidi, Zineb Qmichou, Nadia Dakka, Caroline Diorio, Antje Richter and 2 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Methylation of theOncology letters · 2026
    Article
  2. Higher Levels ofMedical sciences (Basel, Switzerland) · 2026
    Article
  3. Genes · 2026
    Article
  4. Article
  5. Review
  6. Review
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  8. Review
  9. Decoding the Epigenome of Breast Cancer.International journal of molecular sciences · 2025
    Review
  10. The Genomic and Biologic Landscapes of Breast Cancer and Racial Differences.International journal of molecular sciences · 2024
    Review
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Yassire OubaddouLaboratory of Biology of Human Pathologies (BioPatH), Faculty of Sciences, Mohammed V University in Rabat, Rabat 10001, Morocco.ORCID 0009-0003-4077-0835
Mohamed OukabliService of Anatomical Pathology, Military Hospital of Instruction Mohammed V (HMIMV-R), Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10001, Morocco.
Salma FennicheLaboratory of Biology of Human Pathologies (BioPatH), Faculty of Sciences, Mohammed V University in Rabat, Rabat 10001, Morocco.
Abderrahim ElktaibiService of Anatomical Pathology, Military Hospital of Instruction Mohammed V (HMIMV-R), Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10001, Morocco.
Mohamed Reda ElochiService of Anatomical Pathology, Military Hospital of Instruction Mohammed V (HMIMV-R), Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10001, Morocco.
Abderrahmane Al BouzidiCabinet Anatomie Pathologique Essaada, Rabat 10001, Morocco.
Zineb QmichouMedical Biotechnology Center, Moroccan Foundation for Advanced Science, Innovation and Research (MAScIR), Rabat 10001, Morocco.
Nadia DakkaLaboratory of Biology of Human Pathologies (BioPatH), Faculty of Sciences, Mohammed V University in Rabat, Rabat 10001, Morocco.
Caroline DiorioCancer Research Center, CHU de Québec-Université Laval Research Center, Oncology Division, Québec, QC G1R 3S3, Canada.ORCID 0000-0001-5355-7345
Antje RichterInstitute for Genetics, University Giessen, 35392 Giessen, Germany.ORCID 0000-0002-9392-1495
Youssef BakriLaboratory of Biology of Human Pathologies (BioPatH), Faculty of Sciences, Mohammed V University in Rabat, Rabat 10001, Morocco.
Rabii Ameziane El HassaniLaboratory of Biology of Human Pathologies (BioPatH), Faculty of Sciences, Mohammed V University in Rabat, Rabat 10001, Morocco.ORCID 0000-0002-5895-1197
Mohammed V University · MAMoroccan Foundation for Advanced Science, Innovation and Research · MAUniversité Laval · CA

Funding

Agence Nationale Des Plantes Médicinales Et Aromatiques 'ANPMA'OCP Group (Morocco) The Moroccan Ministry of Higher Education, Scientific Research and Innovation and the OCP Foundation who funded this work through the APRD research program
6 · The paper itself

Abstract

The hypermethylation status of the promoter region of the breast cancer 1 (

Indexed as

Biomarkers, TumorBRCA1 ProteinBreast NeoplasmsDNA MethylationPromoter Regions, GeneticAdultAgedClinical RelevanceEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedRetrospective StudiesBiomarkers, TumorBRCA1 ProteinBRCA1 protein, humanbenign breast lesionsbiomarkerBRCA1 promoter hypermethylationbreast cancersmethylation-specific PCRnormal adjacent tissue

Identifiers

PMID37761820
PMCPMC10530732
OpenAlexW4386168635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.