Evidence map›Paper›PMID 37761449›Full record

ArticleChildren (Basel, Switzerland)2023

Rectal Biopsy for Hirschsprung's Disease: A Multicentre Study Involving Biopsy Technique, Pathology and Complications.

Gil Vervloet, Antoine De Backer, Stijn Heyman, Paul Leyman, Sebastiaan Van Cauwenberge, Kim Vanderlinden, Charlotte Vercauteren, Dirk Vervloessem, Marc Miserez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Gil VervloetUniversitair Ziekenhuis Leuven, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Antoine De BackerUniversitair Ziekenhuis Brussel, KidZ Health Castle, Saffier Network, 1000 Brussels, Belgium.
Stijn HeymanZiekenhuis Netwerk Antwerpen, Ziekenhuis aan de Stroom, Queen Paola Children's Hospital, Saffier Network, 2650 Edegem, Belgium.
Paul LeymanGasthuiszusters Antwerpen, Ziekenhuis aan de Stroom, Saffier Network, 2000 Antwerpen, Belgium.
Sebastiaan Van CauwenbergeAlgemeen Ziekenhuis Sint-Jan, 8000 Brugge, Belgium.
Kim VanderlindenUniversitair Ziekenhuis Brussel, KidZ Health Castle, Saffier Network, 1000 Brussels, Belgium.
Charlotte VercauterenUniversitair Ziekenhuis Brussel, KidZ Health Castle, Saffier Network, 1000 Brussels, Belgium.
Dirk VervloessemZiekenhuis Netwerk Antwerpen, Ziekenhuis aan de Stroom, Queen Paola Children's Hospital, Saffier Network, 2650 Edegem, Belgium.ORCID 0000-0003-0450-4276
Marc MiserezUniversitair Ziekenhuis Leuven, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-7047-6114
Universitair Ziekenhuis Brussel · BEZiekenhuisnetwerk Antwerpen Stuivenberg · BEUniversitair Ziekenhuis Leuven · BEAZ Sint-Jan · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe heterogeneity of rectal biopsy techniques has encouraged us to search for a surgical and pathological standardisation of this diagnostic technique to exclude Hirschsprung's disease. The different amounts of information on the anatomopathology report prompted us to compile a template for the anatomopathology report for diagnostic rectal biopsies for surgical colleagues and pathologists working on Hirschsprung's disease.

methodsWe gathered the anonymous biopsy information and its pathology information from five hospitals for all patients in which rectal biopsies were taken to diagnose Hirschsprung's disease over two years (2020-2021).

resultsOf the 82 biopsies, 20 suction (24.4%), 31 punch (37.8%) and 31 open biopsies (37.8%) were taken. Of all biopsies, 69 were conclusive (84.2%), 13 were not (15.8%). In the suction biopsy group, 60% were conclusive and 40% were not; for punch biopsy, the values were 87% and 13%, respectively and for open biopsy, 97% and 3%. Inconclusive results were due to insufficient submucosa in 6/8 suction biopsies, 4/4 punch biopsies and 0/1 open biopsies. An insufficient amount of submucosa was the reason for an inconclusive result in 6/20 cases (30%) after suction biopsy, 4/31 (12.9%) cases after punch biopsy and 0 cases (0%) after open biopsy. We had one case with major postoperative bleeding post suction biopsy; there were no further adverse effects after biopsy.

conclusionsDiagnostic rectal biopsies in children are safe. Non-surgical biopsies are more likely to give inconclusive results due to smaller amounts of submucosa present in the specimen. Open biopsies are especially useful when previous non-surgical biopsies are inconclusive. An experienced pathologist is a key factor for the result. The anatomopathology report should specify the different layers present in the specimen, the presence of ganglion cells and hypertrophic nerve fibres, their description and a conclusion.

Indexed as

Hirschsprung’s diseasepathology Hirschsprungpunch biopsyrectal biopsysuction biopsy

Identifiers

PMID37761449
PMCPMC10530156
OpenAlexW4386332538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.