Evidence map›Paper›PMID 37761381›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Volume-Assisted Estimation of Remnant Liver Function Based on Gd-EOB-DTPA Enhanced MR Relaxometry: A Prospective Observational Trial.

Niklas Verloh, Carolina Rio Bartulos, Kirsten Utpatel, Frank Brennfleck, Andrea Goetz, Andreas Schicho, Claudia Fellner, Dominik Nickel, Florian Zeman, Johannes F Steinmann and 5 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Niklas VerlohDepartment of Radiology, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-8424-5827
Carolina Rio BartulosInstitut für Röntgendiagnostik und Nuklearmedizin, Städtisches Klinikum Braunschweig gGmbH, 38114 Braunschweig, Germany.ORCID 0000-0003-1203-127X
Kirsten UtpatelDepartment of Pathology, University Regensburg, 95053 Regensburg, Germany.
Frank BrennfleckDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.
Andrea GoetzDepartment of Radiology, University Hospital Regensburg, 93053 Regensburg, Germany.
Andreas SchichoDepartment of Radiology, University Hospital Regensburg, 93053 Regensburg, Germany.
Claudia FellnerDepartment of Radiology, University Hospital Regensburg, 93053 Regensburg, Germany.
Dominik NickelMR Applications Predevelopment, Siemens Healthcare GmbH, 91052 Erlangen, Germany.ORCID 0000-0002-0360-7233
Florian ZemanCenter for Clinical Trials, University Hospital Regensburg, 93053 Regensburg, Germany.
Johannes F SteinmannDepartment of Anesthesiology, University Medical Center Regensburg, 93053 Regensburg, Germany.
Wibke UllerDepartment of Diagnostic and Interventional Radiology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0001-6756-9005
Christian StroszczynskiDepartment of Radiology, University Hospital Regensburg, 93053 Regensburg, Germany.
Hans-Jürgen SchlittDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-3874-0296
Phillip WiggermannInstitut für Röntgendiagnostik und Nuklearmedizin, Städtisches Klinikum Braunschweig gGmbH, 38114 Braunschweig, Germany.
Michael HaimerlDepartment of Radiology, University Hospital Regensburg, 93053 Regensburg, Germany.
University Hospital Regensburg · DEKlinikum Braunschweig · DEUniversity of Freiburg · DESiemens Healthineers (Germany) · DEUniversity of Regensburg · DE

Funding

Bayer AG, Berlin, Germany N/A
6 · The paper itself

Abstract

In the context of liver surgery, predicting postoperative liver dysfunction is essential. This study explored the potential of preoperative liver function assessment by MRI for predicting postoperative liver dysfunction and compared these results with the established indocyanine green (ICG) clearance test. This prospective study included patients undergoing liver resection with preoperative MRI planning. Liver function was quantified using T1 relaxometry and correlated with established liver function scores. The analysis revealed an improved model for predicting postoperative liver dysfunction, exhibiting an accuracy (ACC) of 0.79, surpassing the 0.70 of the preoperative ICG test, alongside a higher area under the curve (0.75). Notably, the proposed model also successfully predicted all cases of liver failure and showed potential in predicting liver synthesis dysfunction (ACC 0.78). This model showed promise in patient survival rates with a Hazard ratio of 0.87, underscoring its potential as a valuable tool for preoperative evaluation. The findings imply that MRI-based assessment of liver function can provide significant benefits in the early identification and management of patients at risk for postoperative liver dysfunction.

Indexed as

gadoxetic acid-enhanced MRI (Gd-EOB-DTPA)liver dysfunctionliver resectionmagnetic resonance imaging (MRI)postoperative remnant liver functionsmall for size syndrome

Identifiers

PMID37761381
PMCPMC10529888
OpenAlexW4386912592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.