Evidence map›Paper›PMID 37761137›Full record

ArticleFoods (Basel, Switzerland)2023

Lipid-Lowering Effects of a Novel Polysaccharide Obtained from Fuzhuan Brick Tea In Vitro.

Wenjuan Yang, Shirui Cheng, Meng Liu, Nan Li, Jing Wang, Wenbo Yao, Fuxin Chen, Jianwu Xie, Pin Gong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. The Characterization of a New AG-II-like Glycoprotein fromCurrent issues in molecular biology · 2026
    Article
  2. Medicinal Value ofInternational journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wenjuan YangSchool of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.ORCID 0000-0001-5336-6258
Shirui ChengSchool of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Meng LiuSchool of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Nan LiSchool of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Jing WangSchool of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Wenbo YaoSchool of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.ORCID 0000-0002-8488-4450
Fuxin ChenSchool of Chemistry and Chemical Engineering, Xi'an University of Science and Technology, Xi'an 710054, China.
Jianwu XieSchool of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.ORCID 0000-0002-4982-4671
Pin GongSchool of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Shaanxi University of Science and Technology · CNXi'an University of Science and Technology · CN

Funding

11 key industrial chain projects from Yanan science and technology bureau 2022SLZDCY-006Doctoral Research Initiation Fund of Shaanxi University of Science and Technology 2022BJ-29General Plan of Shaanxi Province 2020GY-236, 2022NY-035Key Industrial Chain Projects of the Shaanxi Province-Agricultural Field 2021ZDLNY04-01,2022ZDLNY04-05National Key Research and Development Program 2021YFD1600400project from Qinchuang Yuan "Scientist& Engineers" Team S2022-ZC-QCYK-0011Project from the Xi'an City Innovation Plan-Agricultural Field 21NYYF0022, 20NYYF0022, 22NYYF048, 22NYYF038Project from Weiyang Technology Bureau 202131projects of the Education Department of Shaanxi Province 22JC021
6 · The paper itself

Abstract

Lipid accumulation causes diseases such as obesity and abnormal lipid metabolism, thus impairing human health. Tea polysaccharide is one of the natural, active substances that can lower lipid levels. In this paper, an oleic-acid-induced HepG2 cell model was established. The lipid-lowering effects of a novel group of Fuzhuan brick tea polysaccharides (FTPs)-obtained from Fuzhuan brick tea-were examined in vitro. The monosaccharide composition of FTP3 was Glc, Gal, Ara, Man, Rha, GalAc, GlcAc, and Xyl with a molar ratio of 23.5:13.2:9.0:5.5:5.4:2.7:1.3:1.0, respectively. A molecular weight of 335.68 kDa was identified for FTP3. HepG2 cells treated with FTP3 achieved a prominent lipid-lowering effect compared with cells treated with oleic acid. Images of the Oil Red O staining treatment showed that FTP3-treated groups had significantly fewer red fat droplets. TC and TG levels were lower in FTP3-treated groups. FTP3 alleviated lipid accumulation in HepG2 cells, activated AMPK, and decreased the SREBP-1C and FAS protein expressions associated with fatty acid synthesis. FTP3 holds promising potential for its lipid-lowering effects.

Indexed as

AMPK/SREBP-1c/FAS pathwayFuzhuan brick tea polysaccharideslipid lowering

Identifiers

PMID37761137
PMCPMC10527736
OpenAlexW4386777203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.