ReviewBiomedicines2023
From Reward to Anhedonia-Dopamine Function in the Global Mental Health Context.
Review in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Dopaminergic Identity of SH-SY5Y Cells Across Differentiation Protocols in Parkinson's Disease Research: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Biopsychosocial and Environmental Factors That Impact Brain-Gut-Microbiome Interactions in Obesity.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Pooled it
- Loneliness, Genetic Susceptibility, Brain Structure, and the Risk of Schizophrenia: A Large Prospective Study.Schizophrenia bulletin · 2026Article
- Association Between Self-Reported Pornographic Consumption Habits and Anxiety and Depression: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Neurobiology of Anxiety and Depression in CP/CPPS: A Narrative Review of Underlying Mechanisms.Neurology international · 2026Review
- Chronic Pain and Opioids in the Elderly: Treating the Brain, Not Just the Body.International journal of environmental research and public health · 2026Review
- Eveningness in Middle-Aged and Older Adults: Associations With Sleep, Internalising Symptoms, and Alertness.Journal of sleep research · 2026Article
- Motivational neurobehavioral abnormalities under a naturalistic goal-conflict task in patients with premenstrual dysphoric disorder.Frontiers in psychiatry · 2026Article
- Altered core depressive symptom balance in post-COVID fatigue: reduced depressed mood in an exploratory matched historical-control study.Frontiers in psychiatry · 2026Article
- [Psychocardiology].Der Nervenarzt · 2026Review
- Growth, development, and health status of primary school students in Binzhou city: an analysis based on health examination data for 6-12-Year-olds.Frontiers in public health · 2026Article
- The temporal stability of core symptoms of social media addiction and their comorbidity with anxiety and depression in adolescents: a longitudinal network analysis.Frontiers in psychiatry · 2026Article
- Exploring procrastination and anhedonia among medical science students at Jahrom University: a qualitative content analysis.BMC medical education · 2025Article
- Dopaminergic Homeostatic Therapy (DHTActa scientific neurology · 2025Article
- Exploring the Connection between Sleep Disorders, Emotional Distress, and Quality of Life in Functional Dyspepsia.Actas espanolas de psiquiatria · 2025Article
- The Role of Dopamine in Neurological, Psychiatric, and Metabolic Disorders and Cancer: A Complex Web of Interactions.Biomedicines · 2025Article
- Review
- The Gut Microbiota-anxiety Connection: Evidence, Mechanisms, and Therapeutic Strategies.Current medicinal chemistry · 2025Review
- The Limbic System in Co-Occurring Substance Use and Anxiety Disorders: A Narrative Review Using the RDoC Framework.Brain sciences · 2024Review
- Predictive Value of Inflammatory Biomarkers in Assessing Major Depression in Adults.Biomedicines · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When "hijacked" by compulsive behaviors that affect the reward and stress centers of the brain, functional changes in the dopamine circuitry occur as the consequence of pathological brain adaptation. As a brain correlate of mental health, dopamine has a central functional role in behavioral regulation from healthy reward-seeking to pathological adaptation to stress in response to adversity. This narrative review offers a spotlight view of the transition from healthy reward function, under the control of dopamine, to the progressive deregulation of this function in interactions with other brain centers and circuits, producing what may be called an anti-reward brain state. How such deregulation is linked to specific health-relevant behaviors is then explained and linked to pandemic-related adversities and the stresses they engendered. The long lockdown periods where people in social isolation had to rely on drink, food, and digital rewards via the internet may be seen as the major triggers of changes in motivation and reward-seeking behavior worldwide. The pathological adaptation of dopamine-mediated reward circuitry in the brain is discussed. It is argued that, when pushed by fate and circumstance into a physiological brain state of anti-reward, human behavior changes and mental health is affected, depending on individual vulnerabilities. A unified conceptual account that places dopamine function at the centre of the current global mental health context is proposed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.