Evidence map›Paper›PMID 37760626›Full record

ReviewCancers2023

MRI-Guided Radiation Therapy for Prostate Cancer: The Next Frontier in Ultrahypofractionation.

Cecil M Benitez, Michael L Steinberg, Minsong Cao, X Sharon Qi, James M Lamb, Amar U Kishan, Luca F Valle

Abstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Magnetic Resonance Imaging Sequences and Technologies in Adaptive Radiation Therapy.International journal of radiation oncology, biology, physics · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cecil M BenitezDepartment of Radiation Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-6951, USA.
Michael L SteinbergDepartment of Radiation Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-6951, USA.
Minsong CaoDepartment of Radiation Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-6951, USA.
X Sharon QiDepartment of Radiation Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-6951, USA.
James M LambDepartment of Radiation Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-6951, USA.
Amar U KishanDepartment of Radiation Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-6951, USA.
Luca F ValleDepartment of Radiation Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-6951, USA.ORCID 0000-0002-5781-4174

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Technological advances in MRI-guided radiation therapy (MRIgRT) have improved real-time visualization of the prostate and its surrounding structures over CT-guided radiation therapy. Seminal studies have demonstrated safe dose escalation achieved through ultrahypofractionation with MRIgRT due to planning target volume (PTV) margin reduction and treatment gating. On-table adaptation with MRI-based technologies can also incorporate real-time changes in target shape and volume and can reduce high doses of radiation to sensitive surrounding structures that may move into the treatment field. Ongoing clinical trials seek to refine ultrahypofractionated radiotherapy treatments for prostate cancer using MRIgRT. Though these studies have the potential to demonstrate improved biochemical control and reduced side effects, limitations concerning patient treatment times and operational workflows may preclude wide adoption of this technology outside of centers of excellence. In this review, we discuss the advantages and limitations of MRIgRT for prostate cancer, as well as clinical trials testing the efficacy and toxicity of ultrafractionation in patients with localized or post-prostatectomy recurrent prostate cancer.

Indexed as

MRIMRI-guided radiotherapyprostate cancerradiation oncologyradiotherapySBRTultrahypofractionation

Identifiers

PMID37760626
PMCPMC10526919

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.