Evidence map›Paper›PMID 37760620›Full record

ArticleCancers2023

Radiomic Assessment of Radiation-Induced Alterations of Skeletal Muscle Composition in Head and Neck Squamous Cell Carcinoma within the Currently Clinically Defined Optimal Time Window for Salvage Surgery-A Pilot Study.

Matthias Santer, Herbert Riechelmann, Benedikt Hofauer, Joachim Schmutzhard, Wolfgang Freysinger, Annette Runge, Timo Maria Gottfried, Philipp Zelger, Gerlig Widmann, Hanna Kranebitter and 4 more

Abstract read
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In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Matthias SanterDepartment of Otorhinolaryngology-Head and Neck Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Herbert RiechelmannDepartment of Otorhinolaryngology-Head and Neck Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Benedikt HofauerDepartment of Otorhinolaryngology-Head and Neck Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Joachim SchmutzhardDepartment of Otorhinolaryngology-Head and Neck Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Wolfgang FreysingerDepartment of Otorhinolaryngology-Head and Neck Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-2833-3224
Annette RungeDepartment of Otorhinolaryngology-Head and Neck Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Timo Maria GottfriedDepartment of Otorhinolaryngology-Head and Neck Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-1022-6877
Philipp ZelgerDepartment for Hearing, Voice and Speech Disorders, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-6543-7620
Gerlig WidmannDepartment of Radiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Hanna KranebitterDepartment of Radiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Stephanie MangesiusDepartment of Neuroradiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-5790-2724
Julian MangesiusDepartment of Radiation-Oncology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-0855-1870
Florian KocherDepartment of Internal Medicine V (Hematology and Oncology), Comprehensive Cancer Center Innsbruck (CCCI), Medical University of Innsbruck, 6020 Innsbruck, Austria.
Daniel DejacoDepartment of Otorhinolaryngology-Head and Neck Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-9176-7415

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) frequently require primary radiochemotherapy (RCT). Despite intensity modulation, the desired radiation-induced effects observed in HNSCC may also be observed as side effects in healthy tissue, e.g., the sternocleidomastoid muscle (SCM). These side effects (e.g., tissue fibrosis) depend on the interval between the completion of RCT and restaging CT. For salvage surgery, the optimal time window for surgery is currently clinically postulated at between 6 and 12 weeks after completion of RCT. Thus, no extensive tissue fibrosis is to be expected. This interval is based on clinical studies exploring surgical complications. Studies directly exploring radiation-induced changes of the SCM in HNSCC patients are sparse. The present study quantified tissue alterations in the SCM and paravertebral musculature (PVM) after RCT, applying radiomics to determine the optimal time window for salvage surgery. Three radiomic key parameters, (1) volume, (2) mean positivity of pixels (MPP), and (3) uniformity, were extracted with mint Lesion

Indexed as

body compositioncomputed tomography scanhead and neck cancerhead and neck neoplasmshead and neck squamous cell carcinomaradiochemotherapyradiomicsradiotherapysalvage surgeryskeletal muscletime interval

Identifiers

PMID37760620
PMCPMC10527389

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.