Evidence map›Paper›PMID 37760619›Full record

ArticleCancers2023

Clinical Outcomes in AYAs (Adolescents and Young Adults) Treated with Proton Therapy for Uveal Melanoma: A Comparative Matching Study with Elder Adults.

Alessia Pica, Damien C Weber, Claude Schweizer, Aziz Chaouch, Leonidas Zografos, Ann Schalenbourg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Alessia PicaCenter for Proton Therapy, Paul Scherrer Institute, ETH Domain, 5232 Villigen West, Switzerland.
Damien C WeberCenter for Proton Therapy, Paul Scherrer Institute, ETH Domain, 5232 Villigen West, Switzerland.
Claude SchweizerDepartment of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, FAA (Fondation Asile des Aveugles), 1004 Lausanne, Switzerland.
Aziz ChaouchDepartment of Epidemiology and Health Systems, Center for Primary Care and Public Health (Unisanté), University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0001-9893-0465
Leonidas ZografosDepartment of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, FAA (Fondation Asile des Aveugles), 1004 Lausanne, Switzerland.
Ann SchalenbourgDepartment of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, FAA (Fondation Asile des Aveugles), 1004 Lausanne, Switzerland.
Fondation Asile des Aveugles · CHCentre universitaire de médecine générale et santé publique, Lausanne · CHPaul Scherrer Institute · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to compare the clinical outcomes of adolescents and young adults (AYAs) with those of elder adult patients treated with proton therapy (PT) for uveal melanoma (UM). MATERIAL AND

methodsA retrospective, comparative study was conducted in UM patients who underwent PT at the Ocular Oncology Unit of the Jules-Gonin Eye Hospital (University of Lausanne, Lausanne, Switzerland) and the Paul Scherrer Institute (PSI); (Villigen, Switzerland) between January 1997 and December 2007. Propensity score matching (PSM) was used to select for each AYA (between 15-39 years old) an elder adult patient (≥40 years) with similar characteristics. We assessed ocular follow-up, local tumor control, metastasis incidence, and overall and relative survival (OS and RS). Non-terminal outcomes were then compared between the two groups using competing risk survival analysis.

resultsOut of a total of 2261 consecutive UM patients, after excluding 4 children (<15 years) and 6 patients who were metastatic at presentation, we identified 272 AYA patients and matched 270 of them with 270 elder adult patients. Before PSM, the AYA patients had a higher incidence of primary iris melanoma (4.0% vs. 1.4%;

conclusionWhile AYAs treated with PT for UM have similar ocular outcomes and present the same metastasis incidence and OS as elder adults, their RS is worse than that in elder adults, when compared with the population in general.

Indexed as

adolescentsAYAeye tumorlocal tumor controlmetastasis incidencepropensity score matchingproton therapyPSMsurvivalteenagersTYAuveal melanomayoung adults

Identifiers

PMID37760619
PMCPMC10526519
OpenAlexW4386880424

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.