Evidence map›Paper›PMID 37760512›Full record

ArticleCancers2023

Microscopical Variables and Tumor Inflammatory Microenvironment Do Not Modify Survival or Recurrence in Stage I-IIA Lung Adenocarcinomas.

Andrea Dell'Amore, Alessandro Bonis, Luca Melan, Stefano Silvestrin, Giorgio Cannone, Fares Shamshoum, Alberto Zampieri, Federica Pezzuto, Fiorella Calabrese, Samuele Nicotra and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Andrea Dell'AmoreThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.
Alessandro BonisThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.ORCID 0000-0001-9422-0597
Luca MelanThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.
Stefano SilvestrinThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.
Giorgio CannoneThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.ORCID 0000-0003-4242-6168
Fares ShamshoumThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.
Alberto ZampieriThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.ORCID 0009-0005-0282-776X
Federica PezzutoPathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-8023-3108
Fiorella CalabresePathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.
Samuele NicotraThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.
Marco SchiavonThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.
Eleonora FaccioliThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.
Marco MammanaThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.
Giovanni Maria ComacchioThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.
Giulia PaselloOncology 2 Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy.
Federico ReaThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DSCTV, University of Padova, 35128 Padova, Italy.
University of Padua · ITIstituto Oncologico Veneto · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microscopical predictors and Tumor Immune Microenvironment (TIME) have been studied less in early-stage NSCLC due to the curative intent of resection and the satisfactory survival rate achievable. Despite this, the emerging literature enforces the role of the immune system and microscopical predictors as prognostic variables in NSCLC and in adenocarcinomas (ADCs) as well. Here, we investigated whether cancer-related microscopical variables and TIME influence survival and recurrence in I-IIA ADCs. We retrospectively collected I-IIA ADCs treated (lobectomy or segmentectomy) at the University Hospital (Padova) between 2016 and 2022. We assigned to pathological variables a cumulative pathological score (PS) resulting as the sum of them. TIME was investigated as tumor-infiltrating lymphocytes (TILs < 11% or ≥11%) and PD-L1 considering its expression (<1% or ≥1%). Then, we compared survival and recurrence according to PS, histology, TILs and PD-L1. A total of 358 I-IIA ADCs met the inclusion criteria. The median PS grew from IA1 to IIA, indicating an increasing microscopical cancer activity. Except for the T-SUVmax, any pathological predictor seemed to be different between PD-L1 < 1% and ≥1%. Histology, PS, TILs and PD-L1 were unable to indicate a survival difference according to the Log-rank test (

Indexed as

adenocarcinomasearly-stage lung adenocarcinomalung cancerpathological scorepathological variablesPD-L1TILstumor microenvironment

Identifiers

PMID37760512
PMCPMC10527442
OpenAlexW4386748276

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.