ArticleAnimals : an open access journal from MDPI2023
Nociception in Chicken Embryos, Part III: Analysis of Movements before and after Application of a Noxious Stimulus.
Article in Animals : an open access journal from MDPI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Development of the capacity to suffer in embryos and chicks: a systematic review of relevant studies.Frontiers in veterinary science · 2025Pooled it
- Hypothalamic c-Fos expression changes during late chicken embryonic development and increases following experimental stimulation.Scientific reports · 2026Article
- Feasibility of High-Frequency Ultrasound and Magnetic Resonance Imaging to Assess the In Ovo Development of Chicken Embryos.Journal of imaging · 2026Article
- In ovo sexing and genotyping using PCR techniques: a contribution to the 3R principles in chicken breeding.Scientific reports · 2026Article
- Evolution of the Chick Embryo Chorioallantoic Membrane Proteome during Early Development.ACS omega · 2026Article
- Pharmacokinetics and analgesic efficacy of fentanyl and buprenorphine in chicken embryos.PloS one · 2026Article
- Polypyrrole Coatings as Possible Solutions for Sensing and Stimulation in Bioelectronic Medicines.Biosensors · 2025Article
- Autoradiography of Intracerebral Tumours in the Chick Embryo Model: A Feasibility Study Using Different PET Tracers.Molecular imaging and biology · 2025Article
- The Chicken Embryo: An Alternative Animal Model in Development, Disease and Pharmacological Treatment.Pharmacology research & perspectives · 2025Review
- The avian embryo as a time-honoured animal model in developmental, biomedical and agricultural research.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Molecular responses of chicken embryos to maternal heat stress through DNA methylation and gene expression: a pilot study.Environmental epigenetics · 2025Article
- Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Many potentially noxious interventions are performed on chicken embryos in research and in the poultry industry. It is therefore essential and in the interest of animal welfare to be able to precisely define the point at which a chicken embryo is capable of nociception in ovo. The present part III of a comprehensive study examined the movements of developing chicken embryos with the aim of identifying behavioral responses to a noxious stimulus. For this purpose, a noxious mechanical stimulus and a control stimulus were applied in a randomized order. The recorded movements of the embryos were evaluated using the markerless pose estimation software DeepLabCut and manual observations. After the application of the mechanical stimulus, a significant increase in beak movement was identified in 15- to 18-day-old embryos. In younger embryos, no behavioral changes related to the noxious stimulus were observed. The presented results indicate that noxious mechanical stimuli at the beak base evoke a nocifensive reaction in chicken embryos starting at embryonic day 15.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.