Evidence map›Paper›PMID 37760189›Full record

ArticleBioengineering (Basel, Switzerland)2023

Efficacy of Fractional Laser on Steroid Receptors in GSM Patients.

Stella Catunda Pinho, Thais Heinke, Paula Fernanda Santos Pallone Dutra, Andreia Carmo, Camilla Salmeron, Luciana Karoleski, Gustavo Focchi, Neila Maria Góis Speck, Beatrice Marina Pennati, Ivaldo Silva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Stella Catunda PinhoDepartment of Gynecology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM, Sao Paulo 04021-001, Brazil.
Thais HeinkeDepartment of Gynecology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM, Sao Paulo 04021-001, Brazil.ORCID 0000-0002-2842-496X
Paula Fernanda Santos Pallone DutraDepartment of Gynecology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM, Sao Paulo 04021-001, Brazil.
Andreia CarmoDepartment of Gynecology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM, Sao Paulo 04021-001, Brazil.
Camilla SalmeronDepartment of Gynecology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM, Sao Paulo 04021-001, Brazil.
Luciana KaroleskiDepartment of Gynecology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM, Sao Paulo 04021-001, Brazil.
Gustavo FocchiDepartment of Gynecology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM, Sao Paulo 04021-001, Brazil.
Neila Maria Góis SpeckDepartment of Gynecology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM, Sao Paulo 04021-001, Brazil.ORCID 0000-0002-3713-5393
Beatrice Marina PennatiClinical Research and Practice Department, El.En. Group, 50041 Calenzano, Italy.ORCID 0000-0001-7288-1845
Ivaldo SilvaDepartment of Gynecology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM, Sao Paulo 04021-001, Brazil.ORCID 0000-0002-2370-943X
Universidade Federal de São Paulo · BREl.En. Group (Italy) · ITØstfold University College · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo compare the efficacy of CO

methodsTwenty-five menopausal women were randomized to receive either laser or estrogen treatment. Vaginal biopsies before and after treatment were compared to assess the amount and distribution of estrogen and progesterone receptors.

resultsEstrogen receptor levels were statistically similar between groups before and after treatment. Although there was no change over time in the estrogen group, an increase in receptor levels was confirmed in the laser group. Changes in estrogen receptor levels showed no association with treatment. Progesterone receptor levels were statistically similar between groups throughout treatment. There was no change over time in both groups. These changes displayed no association with the type of treatment. There was no significant correlation between epithelium thickness and estrogen or progesterone receptor levels.

conclusionsEstrogen and progesterone receptor levels increased and were maintained, respectively, in the vaginal epithelium in both groups. There was no significant relationship between epithelium thickness and receptor density. Laser therapy had similar outcomes to the gold standard without involving the disadvantages of hormone therapy.

Indexed as

estrogengenitourinary syndrome of menopausehormone therapylaser therapymenopause

Identifiers

PMID37760189
PMCPMC10525165
OpenAlexW4386779302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.