ArticleBioengineering (Basel, Switzerland)2023
Bio-Inspired Fiber Reinforcement for Aortic Valves: Scaffold Production Process and Characterization.
Article in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Optimisation of Bioinspired Fibre Architectures for 3D-Printed Polymer Heart Valves via Melt Electrowriting (MEW) Using FE Modelling and Design of Experiments (FE-DOE).Biomimetics (Basel, Switzerland) · 2026Article
- Bioinspired functional materials for biomedical applications.Frontiers in bioengineering and biotechnology · 2026Review
- A comprehensive framework for computational modeling of growth and remodeling in tissue-engineered soft collagenous materials.Biomechanics and modeling in mechanobiology · 2025Article
- Bioengineered heart valves for personalized therapy: advances in manufacturing and clinical challenges.Frontiers in bioengineering and biotechnology · 2025Review
- The Challenge of E-Spinning Sub-Millimeter Tubular Scaffolds-A Design-of-Experiments Study for Fiber Yield Improvement.Polymers · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The application of tissue-engineered heart valves in the high-pressure circulatory system is still challenging. One possible solution is the development of biohybrid scaffolds with textile reinforcement to achieve improved mechanical properties. In this article, we present a manufacturing process of bio-inspired fiber reinforcement for an aortic valve scaffold. The reinforcement structure consists of polyvinylidene difluoride monofilament fibers that are biomimetically arranged by a novel winding process. The fibers were embedded and fixated into electrospun polycarbonate urethane on a cylindrical collector. The scaffold was characterized by biaxial tensile strength, bending stiffness, burst pressure and hemodynamically in a mock circulation system. The produced fiber-reinforced scaffold showed adequate acute mechanical and hemodynamic properties. The transvalvular pressure gradient was 3.02 ± 0.26 mmHg with an effective orifice area of 2.12 ± 0.22 cm
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Registered trials
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